7250121
Tocris Bioscience™ Trametinib
Potent and selective MEK inhibitor; orally bioavailable
Manufacturer: Fischer Scientific
CAS Number: 871700-17-3
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Chemical Name or Material
N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2 H)-yl]phenyl]acetamide
Target
MEK Inhibitors
Purity
0.98
CAS
871700-17-3
Molecular Formula
C26H23FIN5O4
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Trametinib | Fischer Scientific | ₹ 13,313.14 | |
| | Tocris Bioscience™ Trametinib | Fischer Scientific | ₹ 55,314.54 | |
 | Selleck Chemical LLC Trametinib (GSK1120212) 50mg 871700-17-3 JTP-74057, Mekinist | Selleck Chemical LLC | ₹ 66,497.23 | |
| | Selleck Chemical LLC Trametinib (GSK1120212) 5mg 871700-17-3 JTP-74057, Mekinist | Selleck Chemical LLC | ₹ 15,092.78 | |
 | Enzo Life Sciences Trametinib (100mg). CAS: 871700-17-3 | Enzo Life Sciences | ₹ 24,696.89 | |
| | Enzo Life Sciences Trametinib (1g). CAS: 871700-17-3 | Enzo Life Sciences | ₹ 1,37,799.51 | |
| | Enzo Life Sciences Trametinib (200mg). CAS: 871700-17-3 | Enzo Life Sciences | ₹ 37,684.90 | |
| | Enzo Life Sciences Trametinib (50mg). CAS: 871700-17-3 | Enzo Life Sciences | ₹ 18,104.50 | |
 | Biotang Inc Trametinib, > 99%, 200MG, CAS#871700-17-3, M.W.615.39; GSK-1120212, JTP-74057. RS317-200MG | Biotang Inc | ₹ 80,193.68 | |
| | Enzo Life Sciences Trametinib (10mg). CAS: 871700-17-3 | Enzo Life Sciences | ₹ 8,166.70 |
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Description
- Trametinib is a potent and selective MEK1 and MEK2 inhibitor (IC50 = 0.92 and 1.8 nM, respectively, in cell-free assays)
- In vitro , it inhibits the growth of human colorectal cancer cell lines expressing either B-RAF or K-RAF (IC50 values range from 0.48 to 36 nM)
- In vivo , it suppresses tumor growth of HT-29 and COLO205 xenografts in nude mice
- Trametinib induces apoptosis
- This compound is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2 H)-yl]phenyl]acetamide
Target: MEK Inhibitors
Purity: 0.98
CAS: 871700-17-3
Molecular Formula: C26H23FIN5O4
Chemical Name or Material:
N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2 H)-yl]phenyl]acetamide
Target:
MEK Inhibitors
Purity:
0.98
CAS:
871700-17-3
Molecular Formula:
C26H23FIN5O4
Chemical Name or Material: N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
Target: Sirtuin 1/SIRT1
Purity: 0.98
CAS: 925434-55-5
Molecular Formula: C25H23N7OS
Chemical Name or Material:
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
Target:
Sirtuin 1/SIRT1
Purity:
0.98
CAS:
925434-55-5
Molecular Formula:
C25H23N7OS
Chemical Name or Material: N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
Target: Molecular Glues
Purity: 0.98
CAS: 2765625-93-0
Molecular Formula: C20H14F3N3O7S
Chemical Name or Material:
N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
Target:
Molecular Glues
Purity:
0.98
CAS:
2765625-93-0
Molecular Formula:
C20H14F3N3O7S
Chemical Name or Material: 2,4-Dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3 H-1,2,4-triazole-3-thione
Target: Antiviral Compounds
Purity: 0.98
CAS: 675104-49-1
Molecular Formula: C12H12N4O2S2
Chemical Name or Material:
2,4-Dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3 H-1,2,4-triazole-3-thione
Target:
Antiviral Compounds
Purity:
0.98
CAS:
675104-49-1
Molecular Formula:
C12H12N4O2S2