7224933
Tocris Bioscience™ Idelalisib
Potent PI 3-Kinase δ isoform inhibitor
Manufacturer: Fischer Scientific
CAS Number: 870281-82-6
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Chemical Name or Material
5-Fluoro-3-phenyl-2-[(1 S)-1-(9 H-purin-6-ylamino)propyl]-4(3 H)-quinazolinone
Target
PI 3-Kinase Inhibitors
Purity
98%
CAS
870281-82-6
Molecular Formula
C22H18FN7O
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Description
- Idelalisib is a potent PI 3-Kinase δ inhibitor (IC50 = 2.5 nM for p110δ); it exhibits >40-fold selectivity for the δ isoform over other PI 3-K class I enzymes (IC50s = 89, 565, and 820 nM for p110γ, p110β, and p110α respectively)
- Idelalisib blocks constitutive PI 3-K signaling in malignant B-cell lines and primary patient tumor cells
- Idelalisib inhibits chronic lymphocytic leukemia cell chemotaxis and downregulates chemokine secretion triggered by B-cell receptor signaling in stromal cocultures
- Idelalisib lacks significant cytotoxicity toward natural killer (NK) cells
- Idelalisib also decreases production of inflammatory cytokines, including TNF-γ, CD40L, and IL-6 by T cells and IFN-γ by NK cells
- Idelalisib is cell-permeable and orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 5-Fluoro-3-phenyl-2-[(1 S)-1-(9 H-purin-6-ylamino)propyl]-4(3 H)-quinazolinone
Target: PI 3-Kinase Inhibitors
Purity: 98%
CAS: 870281-82-6
Molecular Formula: C22H18FN7O
Chemical Name or Material:
5-Fluoro-3-phenyl-2-[(1 S)-1-(9 H-purin-6-ylamino)propyl]-4(3 H)-quinazolinone
Target:
PI 3-Kinase Inhibitors
Purity:
98%
CAS:
870281-82-6
Molecular Formula:
C22H18FN7O
Chemical Name or Material: N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Target: Additional RTK Inhibitors
Purity: 98%
CAS: 1029044-16-3
Molecular Formula: C20H15ClF3N5
Chemical Name or Material:
N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Target:
Additional RTK Inhibitors
Purity:
98%
CAS:
1029044-16-3
Molecular Formula:
C20H15ClF3N5
Chemical Name or Material: β-D-N4-hydroxycytidine-5 '-isopropyl ester
Target: Antiviral Compounds
Purity: 98%
CAS: 2492423-29-5
Molecular Formula: C13H19N3O7
Chemical Name or Material:
β-D-N4-hydroxycytidine-5 '-isopropyl ester
Target:
Antiviral Compounds
Purity:
98%
CAS:
2492423-29-5
Molecular Formula:
C13H19N3O7
Chemical Name or Material: (3 R,4 S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide
Target: Nrf2 Activators
Purity: 98%
CAS: 2416095-06-0
Molecular Formula: C14H20ClNO4S2
Chemical Name or Material:
(3 R,4 S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide
Target:
Nrf2 Activators
Purity:
98%
CAS:
2416095-06-0
Molecular Formula:
C14H20ClNO4S2