76-315-0
Tocris Bioscience™ Idelalisib
Manufacturer: Fischer Scientific
CAS Number: 870281-82-6
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 76-315-0-Each-of-1 | In Stock | ₹ 30,801.60 |
76-315-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 30,801.60
GST (18%): ₹ 5,544.288
Total Price: ₹ 36,345.888
Chemical Name or Material
5-Fluoro-3-phenyl-2-[(1 S)-1-(9 H-purin-6-ylamino)propyl]-4(3 H)-quinazolinone
Quantity
50 mg
Molecular Formula
C22H18FN7O
CAS
870281-82-6
Target
PI 3-Kinase Inhibitors
Purity
98%
Other Options
Related Products
Description
- Idelalisib is a potent PI 3-Kinase δ inhibitor (IC50 = 2.5 nM for p110δ); it exhibits >40-fold selectivity for the δ isoform over other PI 3-K class I enzymes (IC50s = 89, 565, and 820 nM for p110γ, p110β, and p110α respectively)
- Idelalisib blocks constitutive PI 3-K signaling in malignant B-cell lines and primary patient tumor cells
- Idelalisib inhibits chronic lymphocytic leukemia cell chemotaxis and downregulates chemokine secretion triggered by B-cell receptor signaling in stromal cocultures
- Idelalisib lacks significant cytotoxicity toward natural killer (NK) cells
- Idelalisib also decreases production of inflammatory cytokines, including TNF-γ, CD40L, and IL-6 by T cells and IFN-γ by NK cells
- Idelalisib is cell-permeable and orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: 5-Fluoro-3-phenyl-2-[(1 S)-1-(9 H-purin-6-ylamino)propyl]-4(3 H)-quinazolinone
Quantity: 50 mg
Molecular Formula: C22H18FN7O
CAS: 870281-82-6
Target: PI 3-Kinase Inhibitors
Purity: 98%
Chemical Name or Material:
5-Fluoro-3-phenyl-2-[(1 S)-1-(9 H-purin-6-ylamino)propyl]-4(3 H)-quinazolinone
Quantity:
50 mg
Molecular Formula:
C22H18FN7O
CAS:
870281-82-6
Target:
PI 3-Kinase Inhibitors
Purity:
98%
Chemical Name or Material: N-[3,5-Dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]urea
Quantity: 10 mg
Molecular Formula: C19H14Cl2F3N5O2
CAS: 1268490-12-5
Target: MAPK Inhibitors
Purity: 0.98
Chemical Name or Material:
N-[3,5-Dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]urea
Quantity:
10 mg
Molecular Formula:
C19H14Cl2F3N5O2
CAS:
1268490-12-5
Target:
MAPK Inhibitors
Purity:
0.98
Chemical Name or Material: __
Quantity: 100 μg
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Quantity:
100 μg
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Chemical Name or Material: __
Quantity: 300 μg
Molecular Formula: __
CAS: __
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Chemical Name or Material:
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Quantity:
300 μg
Molecular Formula:
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