7235751

Tocris™ AT 7867

Potent pan-Akt and PKA inhibitor

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Chemical Name or Material

4-(4-Chlorophenyl)-4-[4-(1 H-pyrazol-4-yl)phenyl]piperidine hydrochloride

Target

Akt (Protein Kinase B) Inhibitors

Molecular Formula

C20H20ClN3.HCl

Purity

0.98

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Description

  • AT 7867 is a potent pan-Akt (protein kinase B) and protein kinase A (PKA) inhibitor (IC50 values are 32, 17, 47 and 20 nM for Akt1, Akt2, Akt3 and PKA, respectively)
  • Also inhibits p70-S6 kinase (p70S6K, IC50 = 85 nM)
  • Inhibits Akt signaling and proliferation of multiple human cancer cell lines, including breast, prostate and colon
  • Promotes proliferation of iPSC-derived PDX1+ pancreatic progenitor cells (PPCs).

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C

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