7250164
Tocris Bioscience™ AMZ 30
Potent, selective and irreversible protein phosphatase methylesterase-1 (PME-1) inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1313613-09-0
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Chemical Name or Material
(2 E)-2-[(4-Fluorophenyl)sulfonyl]-3-[1-[(3-nitrophenyl)sulfonyl]-1 H-pyrrol-2-yl]-2-propenenitrile
Target
Hydrolase Inhibitors
Purity
0.98
CAS
1313613-09-0
Molecular Formula
C19H12FN3O6S2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ AMZ 30 | Fischer Scientific | ₹ 15,085.94 | |
| | Tocris Bioscience™ AMZ 30 | Fischer Scientific | ₹ 63,519.74 | |
 | eMolecules Ambeed / (E)-2-((4-Fluorophenyl)sulfonyl)-3-(1-((3-nitrophenyl)sulfonyl)-1H-pyrrol-2-yl)acrylonitrile / 1mg / 761012790 / A781030 / / 1313613-09-0 / MFCD28900741 / 461.440 / C19H12FN3O6S2 | eMolecules | ₹ 3,205.08 | |
 | 1313613-09-0 | AMZ30 | A2B Chem | ₹ 2,053.44 - ₹ 6,417.00 |
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Description
- AMZ 30 is a potent, selective and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 600 nM) with > 100-fold selectivity for PME-1 over other serine hydrolases in human cell lysates
- AMZ 30 inactivates PME-1 and reduces the demethylated form of serine/threonine protein phosphatase 2A (PP2A) in HEK 293T cells
- AMZ 30 perturbs leucine carboxyl methyltransferase-1 (LCMT1)-PME-1 methylation equilibrium leading to shortening of mitotic spindles and mitotic arrest in HeLa cells
- It also shows antiproliferative properties in an in vitro model of endometrial carcinoma.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: (2 E)-2-[(4-Fluorophenyl)sulfonyl]-3-[1-[(3-nitrophenyl)sulfonyl]-1 H-pyrrol-2-yl]-2-propenenitrile
Target: Hydrolase Inhibitors
Purity: 0.98
CAS: 1313613-09-0
Molecular Formula: C19H12FN3O6S2
Chemical Name or Material:
(2 E)-2-[(4-Fluorophenyl)sulfonyl]-3-[1-[(3-nitrophenyl)sulfonyl]-1 H-pyrrol-2-yl]-2-propenenitrile
Target:
Hydrolase Inhibitors
Purity:
0.98
CAS:
1313613-09-0
Molecular Formula:
C19H12FN3O6S2
Chemical Name or Material: 5-Phenyl-1 H-indole-3-acetic acid
Target: Active Degraders
Purity: 0.98
CAS: 168649-23-8
Molecular Formula: C16H13NO2
Chemical Name or Material:
5-Phenyl-1 H-indole-3-acetic acid
Target:
Active Degraders
Purity:
0.98
CAS:
168649-23-8
Molecular Formula:
C16H13NO2
Chemical Name or Material: N-[3-[(5 R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2 H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide
Target: Secretase Inhibitors
Purity: 0.98
CAS: 1286770-55-5
Molecular Formula: C17H17F2N5O3S
Chemical Name or Material:
N-[3-[(5 R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2 H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide
Target:
Secretase Inhibitors
Purity:
0.98
CAS:
1286770-55-5
Molecular Formula:
C17H17F2N5O3S
Chemical Name or Material: N-(5-Chloro-2-pyridinyl)-2-(5 H-1,2,4-triazino[5,6-b]indol-3-ylthio)acetamide
Target: Molecular Glues
Purity: 0.98
CAS: 296771-07-8
Molecular Formula: C16H11ClN6OS
Chemical Name or Material:
N-(5-Chloro-2-pyridinyl)-2-(5 H-1,2,4-triazino[5,6-b]indol-3-ylthio)acetamide
Target:
Molecular Glues
Purity:
0.98
CAS:
296771-07-8
Molecular Formula:
C16H11ClN6OS