7250176
Tocris Bioscience™ Asunaprevir
Potent hepatitis C virus (HCV) NS3 protease inihibitor
Manufacturer: Fischer Scientific
CAS Number: 630420-16-5
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Chemical Name or Material
1-[[N-tert-Butoxycarbonyl-L-tert-leucyl-trans-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-L-prolyl]amino]-N-(cyclopropylsulfonyl)-(1 R,2 S)-2-vinylcyclopropane-1-carboxamide
Target
CRISPR Reagents
Purity
0.98
CAS
630420-16-5
Molecular Formula
C35H46ClN5O9S
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Asunaprevir | Fischer Scientific | ₹ 26,095.80 | |
| | Tocris Bioscience™ Asunaprevir | Fischer Scientific | ₹ 1,09,345.68 | |
 | Medchemexpress LLC Asunaprevir | 630420-16-5 | MFCD27987900 | 10 mm/mL | Medchemexpress LLC | ₹ 20,213.55 | |
 | eMolecules AstaTech / ASUNAPREVIR / 0.01g / 449732111 / 43208 / 95.000 / 630420-16-5 / MFCD27987900 / 748.290 / C35H46ClN5O9S | eMolecules | ₹ 8,690.33 | |
 | Apexbio Technology LLC Asunaprevir (BMS-650032), 10mg. Cas: 630420-16-5 MFCD: MFCD27987900. NS3 protease inhibitor | Apexbio Technology LLC | ₹ 32,512.80 | |
 | (1R,2S)-N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide | Aaron Chemicals LLC | ₹ 2,737.92 - ₹ 1,30,393.44 |
Related Products
Description
- Asunaprevir is a potent HCV NS3 protease inhibitor (IC50 = 0.2-3.5 nM)
- Asunaprevir can be used to control CRIPSR-Cas9 gene editing via the small molecule-assisted shut-off (SMASh) technique, which involves fusion of Cas9 to a peptide comprising a protease domain and a degron tag
- Asuprenavir blocks the protease-mediated removal of the degron tag leading to degradation of Cas9 through proteasome and autophagolysosome pathways
- It can also be used as a resversible switch to control CAR (chimeric antigen receptor)-T cells, where the CAR has been modified by insertion of a hepatitis C virus nonstructural protein 3 protease (HCV-NS3) between the scFv and the hinge domains
- Also inhibits SARS-CoV-2 Mpro activity (IC50 = 15-48.4 μM).
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 1-[[N-tert-Butoxycarbonyl-L-tert-leucyl-trans-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-L-prolyl]amino]-N-(cyclopropylsulfonyl)-(1 R,2 S)-2-vinylcyclopropane-1-carboxamide
Target: CRISPR Reagents
Purity: 0.98
CAS: 630420-16-5
Molecular Formula: C35H46ClN5O9S
Chemical Name or Material:
1-[[N-tert-Butoxycarbonyl-L-tert-leucyl-trans-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-L-prolyl]amino]-N-(cyclopropylsulfonyl)-(1 R,2 S)-2-vinylcyclopropane-1-carboxamide
Target:
CRISPR Reagents
Purity:
0.98
CAS:
630420-16-5
Molecular Formula:
C35H46ClN5O9S
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