74-865-0
Tocris Bioscience™ Roxadustat
Manufacturer: Tocris Bioscience™
CAS Number: 808118-40-3
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 74-865-0-Each-of-1 | In Stock | ₹ 12,731.33 |
74-865-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 12,731.33
GST (18%): ₹ 2,291.639
Total Price: ₹ 15,022.969
Chemical Name or Material
N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine
Quantity
50 mg
Molecular Formula
C19H16N2O5
CAS
808118-40-3
Target
Hydrolase Inhibitors
Purity
0.98
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Description
- Roxadustat is a hypoxia-inducible factor prolyl hydroxylase enzyme (HIF-PH) inhibitor (IC50 = 591.4 nM)
- Roxadustat reduces basal oxygen consumption and increases glycolysis in vitro
- It increases hemoglobin levels and stimulates erythropoiesis in vivo
- By reducing ACE2 expression, roxadustat reduces the levels of SARS-CoV-2 viral RNA and inhibits entry, replication and secretion of infectious particles in lung epithelial cells
- Roxadustat also suppresses hydroxylation and secretion of high molecular weight forms of mannose-binding lectin
- The compound suppresses ion currents in pituitary tumor cells (IC50 values for inhibition of peak and late components of delayed rectifier calcium currents are 5.71 and 1.32 μM, respectively)
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine
Quantity: 50 mg
Molecular Formula: C19H16N2O5
CAS: 808118-40-3
Target: Hydrolase Inhibitors
Purity: 0.98
Chemical Name or Material:
N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine
Quantity:
50 mg
Molecular Formula:
C19H16N2O5
CAS:
808118-40-3
Target:
Hydrolase Inhibitors
Purity:
0.98
Chemical Name or Material: 4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
Quantity: 10 mg
Molecular Formula: C32H35ClFN7O2
CAS: 2326521-71-3
Target: Ras GTPase Inhibitors
Purity: 98%
Chemical Name or Material:
4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
Quantity:
10 mg
Molecular Formula:
C32H35ClFN7O2
CAS:
2326521-71-3
Target:
Ras GTPase Inhibitors
Purity:
98%
Chemical Name or Material: 4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
Quantity: 50 mg
Molecular Formula: C32H35ClFN7O2
CAS: 2326521-71-3
Target: Ras GTPase Inhibitors
Purity: 98%
Chemical Name or Material:
4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
Quantity:
50 mg
Molecular Formula:
C32H35ClFN7O2
CAS:
2326521-71-3
Target:
Ras GTPase Inhibitors
Purity:
98%
Chemical Name or Material: Ethyl (4 R,5 R)-rel-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1 H-imidazole-4-carboxylate
Quantity: 10 mg
Molecular Formula: C39H37N3O3
CAS: 1446350-60-2
Target: Proteasome Modulators
Purity: 0.98
Chemical Name or Material:
Ethyl (4 R,5 R)-rel-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1 H-imidazole-4-carboxylate
Quantity:
10 mg
Molecular Formula:
C39H37N3O3
CAS:
1446350-60-2
Target:
Proteasome Modulators
Purity:
0.98