Thermo Scientific™ CT(PEG)12 Carboxy-PEG-Thiol Compound

Description

• Thermo Scientific™ Pierce CT(PEG)12, or carboxy-PEG12-thiol, is a carboxyl- and sulfhydryl-terminated compound that contains a 12-unit polyethylene glycol (PEG) spacer and is used to modify surfaces such as quantum dots, monolayers and magnetic particles
• CT(PEG)12 is monodentate thiol-terminated and carboxylic acid pegylation reagent
• The PEG compound has a defined molecular weight and spacer length and is useful for modifying surfaces such quantum dots, self-assembled monolayers and magnetic particles
• Functionalization of solid surfaces with this polyethylene glycol reagent provides carboxylate “handles“ for protein immobilization via EDC crosslinking and significantly reduces nonspecific protein binding and provides
• Highlights: Metal-binding – terminal monodentate thiol reacts spontaneously with gold surfaces through dative binding Carboxylate – terminal carboxylic acid group allows conjugation to amine-containing affinity ligands using carbodiimide (EDC) and Sulfo-NHS crosslinking chemistry Polyethylene glycol – PEG groups are flexible, non-immunogenic, hydrophilic, and significantly reduce nonspecific binding of surfaces for protein methods Spacer arm – 12-unit PEG spacer is nearly 48 angstroms long, minimizing steric hindrance for protein immobilization and binding assays Specifications: Alternative name: Carboxy-PEG12-Thiol Chemical name: 1-mercapto-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid Chemical formula: C27H54O14S Molecular weight: 634.77 Spacer arm: 47.8 angstroms Form: colorless to pale yellow liquid Solubility: dissolve in DMSO or DMF for use