41-982-05MG

MilliporeSigma™ Calbiochem™ ITK Inhibitor, BMS-509744

Manufacturer: MilliporeSigma™

CAS Number: 439575-02-7

Select a Size

Pack Size SKU Availability Price
Each of 1 41-982-05MG-Each-of-1 In Stock ₹ 24,076.58

41-982-05MG - Each of 1

₹ 24,076.58

In Stock

Quantity

1

Base Price: ₹ 24,076.58

GST (18%): ₹ 4,333.784

Total Price: ₹ 28,410.364

Color

Pale Yellow

Target Proteins

ITK

Molecular Formula

C32H41N5O4S2

Solubility

DMSO

Form

Powder

Description

97% by HPLC

CAS

439575-02-7

Formula Weight

623.8g/mol

Content And Storage

Protect from light

Quantity

5 mg

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Description

  • A cell-permeable aminothioaryl-thiazolo compound that potently inhibits ITK kinase activity (IC 50 = 19nM; [ATP] = 1μM) in an ATP-competitive manner by stabilizing ITK activation loop in a substrate-blocking, inactive conformation, inhibiting Fyn, IR, Lck, Btk only at much higher concentrations (IC 50 ≥1.1μM) and exhibiting little or no activity against 14 other kinases (IC 50 ≥11μM)
  • Inhibits ITK-dependent cellular signaling (IC 50 <300nM against αCD3-stimulated PLCγ1 Tyr phosphorylation and Ca 2+ mobilization in Jurkat cells) in vitro and alleviate OVA (Cat
  • No
  • 32467) challenge-induced airway leukocytes infiltration (ED 50 = 25mg/kg s.c.) in OVA-sensitized mice in vivo .

Compare Similar Items

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Img

MilliporeSigma™

41-982-05MG

--


Color:
Pale Yellow

Target Proteins:
ITK

Molecular Formula:
C32H41N5O4S2

Solubility:
DMSO

Form:
Powder

Description:
97% by HPLC

CAS:
439575-02-7

Formula Weight:
623.8g/mol

Content And Storage:
Protect from light

Quantity:
5 mg

Img

MilliporeSigma™

41-982-5250MG

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Color:
White

Target Proteins:
__

Molecular Formula:
C35H38Cl2N8O4

Solubility:
DMSO

Form:
Powder

Description:
98% by HPLC

CAS:
84625-61-6

Formula Weight:
705.6g/mol

Content And Storage:
Protect from light

Quantity:
250 mg

Img

Invitrogen

41-984-380

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Color:
__

Target Proteins:
__

Molecular Formula:
__

Solubility:
__

Form:
Liquid

Description:
__

CAS:
__

Formula Weight:
__

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Quantity:
25 μg

Img

Invitrogen

41-989-282

--


Color:
__

Target Proteins:
__

Molecular Formula:
__

Solubility:
__

Form:
Liquid

Description:
__

CAS:
__

Formula Weight:
__

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Quantity:
100 μg