MilliporeSigma™ Calbiochem™ Tankyrase1/2 Inhibitor V, WIKI4

Description

• A cell-permeable triazole derivative that acts as a reversible TNKS inhibitor (IC 50 = 15nM) and selectively inhibits Wnt/β-catenin, but not NF-κB, TGFβ, or retinoic acid, signaling pathway-dependent transcription activity
• Both WIKI4 and XAV939 (Cat
• No
• 575545) are shown to induce basal axin1/2 protein accumulation in DLD1 colon cancer cells (2.5μM; 2 to 4 h) and prevent Wnt3a-induced axin1 protein degradation and β-catenin accumulation in A375 melanoma cells (1μM; up to 24 h) with similar potency
• Likewise, WIKI4 also effectively inhibits the Wnt/β-catenin pathway-dependent growth of DLD1 (by 67% in 10 days;1μM)
• Please note that the molecular weight for this compound is batch-specific due to variable water content
• Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight
• The molecular weight provided represents the baseline molecular weight without water.