MilliporeSigma™ Calbiochem™ Mitaplatin

Description

• A cell-permeable Pt(IV) compound that, upon reduction inside cells, yields two molecules of the PDK (pyruvate dehydrogenase kinase) inhibitor DCA/dichloroacetate and one molecule of the apoptosis inducer Cisplatin (Cat
• No
• 232120)
• While the dual prodrug nature of Mitaplatin is shown to result in increased cell killing than Cisplatin in the human ovarian carcinoma A2780/CP70 cultures (IC 50 = 3.34 and 6.0, respectively), the anticancer potency of Mitaplatin is often weaker than Cisplatin in other cancer cells tested, presumably due to insufficient prodrug reduction in these cells
• Note: Carboplatin, Cisplatin, and other platinum drugs are reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO
• Solubilization with DMSO prior to culture treatment is not recommended.