MilliporeSigma™ Calbiochem™ HDAC Inhibitor XVII

Description

• A cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC 50 = 27nM), displaying much reduced or little potency against HDAC1/3 (IC 50 = 3.0μM), HDAC2/4/6/10/11 (IC 50 >20μM), or total HDAC activity in HeLa nuclear extract (IC 50 >10μM)
• Reported to preferentially inhibit the proliferation of human lung cancer cells CL1-5, H1299, and A549 (IC 50 from 7 to 8μM), while being much less toxic to normal human lung IMR-90 cells (73% inhibition at 40μM).