MilliporeSigma™ Calbiochem™ 5-Azacytidine

Description

• A cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis
• Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage
• Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC 50 < 4.0μM)
• Enhances reprogramming efficiency (EC 50 ∽ 2.4μM in iOSKM-MEFs)
• 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat
• No
• 189825) and (Cat
• No
• 189826).