MilliporeSigma™ Calbiochem™ EBP1 Inhibitor, WS6

Description

• A cell-permeable phenoxypyrimidin-cyclopropanecarboxamide compound that effectively stimulates the growth of primary β cells in cultured primary rat and human islets in vitro (EC max in 4 d = 200 and 400 nM, respectively) and in the murine type 1 diabetes (T1D) model RIP-DTA in vivo (170% of control pancreas Ki-67-positive β cells in 1 wk; 5mg/kg i.p
• q.o.d.) by interacting with IKKε and EBP1/PA2G4/Erb3 binding protein-1 and blocking the known suppressor function of EBP1 toward E2F-mediated transcription
• Likewise, dual inhibition of EBP1 (with shRNA) and IKK (1μM; Cat
• Nos
• 401486 and 505378) is shown to fully recapitulate the proliferating effect of WS6 in R7T1 cells.