MilliporeSigma™ Calbiochem™ Fbxo3 Inhibitor, BC-1215

Description

• A cell-permeable, bis-pyridinylbenzylethanamine that disrupts Fbxo3-Fbxl2 interaction and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in cellular Fbxl2 upregulation and thereby SCF-Fbxl2-catalyzed TRAFs (TNF Receptor-Associated Factors) ubiquitination
• Effectively reduces cellular TRAFs (5 to 127μM) and prevents TRAF-mediated cytokines production from LPS-stimulated human PBMC (25μM)
• Shown to greatly prevent Cecal Ligation & Puncture-induced plasma cytokine elevation and substantially reduce the severity of lung inflammation post intratracheal P
• aeruginosa infection in mice (100μg/mouse; i.p.) in vivo .