MilliporeSigma™ Calbiochem™ HDAC6 Inhibitor II, BRD9757

Description

• A cell-permeable, low molecular weight hydroxamate compound that acts as a potent histone deacetylase class IIb HDAC6-selective inhibitor (IC 50 = 30nM), while inhibiting class I HDAC1/2/3/8 only at higher concentrations (IC 50 = 0.638, 1.79, 0.694, and 1.09μM, respectively) and exhibiting much reduced potency against class IIa HDAC4/5/7/9 (IC 50 >12.61μM)
• Shown to selectively upregulate HDAC6 substrate α-tubulin acetylation in HeLa cells (10 and 30μM; 24 h) without inducing histone H3 acetylation increase seen with another HDAC6-selective inhibitor Tubastatin A (Cat
• No
• 382187)
• Unlike other Zinc-binding group-containing HDAC inhibitors, BRD9757 does not contain an apparent selectivity-imparting capping structure linked to its hydroxamate.