MilliporeSigma™ Calbiochem™ BLM Helicase Inhibitor, ML216

Description

• A cell-permeable pyridinyl-thiadiazolylurea compound that selectively blocks Bloom′s syndrome protein (BLM) helicase activity of both full-length as well as truncated BLM 636-1298 forms (IC 50 = 2.98 and 0.97μM, respectively)
• Competes with and reversibly blocks DNA binding to BLM
• However, the inhibition appears to be non-competitive with respect to ATP
• Exhibits anti-proliferative activity in cells expressing BLM, but not in those lacking BLM
• Induces sister chromatid exchanges (SCEs) and enhances the sensitivity of BLM containing PSNF5 cells to aphidicolin (Cat
• No
• 178273) without affecting PSNG13 cells that are devoid of BLM
• Displays favorable microsomal (T 1/2 > 1.2 h) and plasma stability (∽100% at 5 h).