53-258-30001

MilliporeSigma™ Calbiochem™ TLR1/TLR2 Agonist II, CU-T12-9

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 53-258-30001-Each-of-1 In Stock ₹ 21,595.34

53-258-30001 - Each of 1

₹ 21,595.34

In Stock

Quantity

1

Base Price: ₹ 21,595.34

GST (18%): ₹ 3,887.161

Total Price: ₹ 25,482.501

Color

Yellow

Target Proteins

TLR1/TLR2

Solubility

DMSO

Form

Powder

Description

98% by HPLC

Molecular Formula

C17H13F3N4O2

Content And Storage

Protect from light

Quantity

10 mg

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Description

  • A diphenyl substituted imidazole based compound that directly and selectively targets TLR1/2 and induces their dimerization and activates TLR1 and 2 signaling leading to NF-κB and AP-1 activation ( K D = 182 and 478 nM, respectively; EC 50 = 52.9nM for TLR2 in HEK-Blue cells over-expressing hTLR2)
  • Does not affect the dimerization of TLR2/TLR6 and exhibits poor affinity towards TLR3, TLR4, TLR5, TLR7 and TLR8
  • Shown to compete with Pam 3 CSK 4 (Cat
  • No
  • 506350; K i = 45.4nM) for binding to TLR1/2 interface and enhance heterodimerization
  • Up-regulates the expression of TLR1, TLR2, TNFα, IL-10, and iNOS in RAW 264.7 macrophages in a time-dependent manner
  • Shown to be non-toxic up to 100μM concentration
  • Please note that the molecular weight for this compound is batch-specific due to variable water content.

Compare Similar Items

Show Difference

Img

MilliporeSigma™

53-258-30001

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Color:
Yellow

Target Proteins:
TLR1/TLR2

Solubility:
DMSO

Form:
Powder

Description:
98% by HPLC

Molecular Formula:
C17H13F3N4O2

Content And Storage:
Protect from light

Quantity:
10 mg

Img

MilliporeSigma™

53-258-60001

--


Color:
White

Target Proteins:
Serine proteases

Solubility:
H2O

Form:
Powder

Description:
99% by HPLC

Molecular Formula:
C8H10FNO2S·HCl

Content And Storage:
Protect from Light, Protect from Moisture

Quantity:
250 mg

Img

MilliporeSigma™

53-260-40001

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Color:
Beige

Target Proteins:
MELK

Solubility:
DMSO or H2O

Form:
Powder

Description:
98% by HPLC

Molecular Formula:
C25H30Cl4N4O2

Content And Storage:
Protect from light

Quantity:
5 mg

Img

MilliporeSigma™

53-260-60001

--


Color:
White

Target Proteins:
FLAP

Solubility:
DMSO

Form:
Solid

Description:
98% by HPLC

Molecular Formula:
C34H34ClN2NaO3S

Content And Storage:
Protect from light

Quantity:
5 mg