MilliporeSigma™ Calbiochem™ TLR1/TLR2 Agonist II, CU-T12-9

Description

• A diphenyl substituted imidazole based compound that directly and selectively targets TLR1/2 and induces their dimerization and activates TLR1 and 2 signaling leading to NF-κB and AP-1 activation ( K D = 182 and 478 nM, respectively; EC 50 = 52.9nM for TLR2 in HEK-Blue cells over-expressing hTLR2)
• Does not affect the dimerization of TLR2/TLR6 and exhibits poor affinity towards TLR3, TLR4, TLR5, TLR7 and TLR8
• Shown to compete with Pam 3 CSK 4 (Cat
• No
• 506350; K i = 45.4nM) for binding to TLR1/2 interface and enhance heterodimerization
• Up-regulates the expression of TLR1, TLR2, TNFα, IL-10, and iNOS in RAW 264.7 macrophages in a time-dependent manner
• Shown to be non-toxic up to 100μM concentration
• Please note that the molecular weight for this compound is batch-specific due to variable water content.