MilliporeSigma™ Calbiochem™ Transglutaminase 2 Inhibitor, ZDON

Description

• A cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC 50 = 150nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2
• Exhibits far less potency against TG1 and TG3
• Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (∽50 mM)
• Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells
• Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.