MilliporeSigma™ Calbiochem™ V-ATPase Inhibitor, KM91104

Description

• A cell-permeable, non-macrolide small molecule V-ATPase inhibitor that specifically targets the a3-b2 subunit protein protein interation of V-ATPase (IC 50 of 2.3μM), in vitro
• It is also shown to inhibit osteoclast resorption (IC 50 of 1.2μM) on both synthetic hydroxyapatite surfaces and dentin slices in an in vitro osteoclast model, RANKL-differentiated RAW 264.7 cells, without significantly affecting RAW 264.7 cell viability or RANKL-mediated osteoclast differentiation.