Anti-ASC Antibody, clone 2EI-7

Description

• General description: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, Bcl10, Apaf-1, ARC, caspase-2 and caspase-9. A novel CARD domain containing protein has been identified in human and mouse and designated ASC and TMS1. Irregular expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.
• Specificity: This antibody recognizes ASC.
• Immunogen: Epitope: Unknown
• Application: Detect ASC using this Anti-ASC Antibody, clone 2EI-7 validated for use in WB, FC.
• Quality: Evaluated by Western Blot on mouse spleen tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected ASC in mouse spleen tissue lysate.
• Target description: ~22 kDa
• Physical form: Format: Purified
• Storage and Stability: Stable for 1 year at 2-8°C from date of receipt.
• Analysis Note: ControlMouse spleen tissue lysate
• Other Notes: Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.