Anti-EEA1 Antibody

Description

• General description: Early endosome antigen 1 (EEA1) is a 170 kDa coiled-coil protein belonging to a group of early endosomal Rab5 effector proteins. EEA1 has a putative role in the tethering/docking of endocytic vesicles prior to their fusion with early endosomes. This protein is characterized as containing a zinc finger-like domain and coiled-coil regions. The zinc finger-like domain, also known as the FYVE finger, is a motif rich in cystine, is a necessary component of EEA1’s ability for endosomal targeting, and is specifically known for its dual interaction with Rab5 GTPase and phosphotidylinositol 3-phosphate (Ptdlns-3-P).
• Specificity: Equine and Canine (99% sequence homology). Rat (98% sequence homology). Bovine (97% sequence homology).
• Immunogen: Epitope: C-terminus
• Application: Research CategorySignaling
• Quality: Evaluated by Western Blot in BALB 3T3/A31 cell lysate.Western Blot Analysis: A 1:1000 dilution of this antibody detected EEA1 on 10 µg of BALB 3T3/A31 cell lysate.
• Target description: ~ 170 kDa
• Physical form: Affinity purified
• Storage and Stability: Stable for 1 year at 2-8°C from date of receipt.
• Analysis Note: ControlBALB 3T3/A31 cell lysate
• Other Notes: Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.