Anti-GRP78/BiP (ET-21) antibody produced in rabbit

Description

• Application: Anti-GRP78/BiP (ET-21) antibody produced in rabbit is suitable for use as a primary antibody: for immunofluorescence staining of frozen heart tissue to examine whether ER stress signaling activation occurs in cardiomyocytesfor immunohistochemistry on Paraffin embedded sections of human cerebral cortex and human thyroid gland tissue sections.to detect Bip by immunoblotting of protein extract from WT AB strain of zebrafish (Danio rerio)at a working dilution of 1:1000 to detect GRP78 in extract of prostate cancer cells after androgen deprivation therapyIt is also suitable for immunoblotting at a working dilution of 1:3000 using human epitheloid carcinoma HeLa whole cell extract and for immunocytochemistry at a working dilution of 1:1000 using mouse fibroblasts NIH3T3 cells.
• Biochem/physiol Actions: GRP78/BiP levels are elevated in Alzheimer′s disease brains and the decreased expression of GRP78/BiP is found associated with missense mutations in presenilin-1 (PS-1).
• Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.