Anti-MAP2 (2a+2b) antibody, Mouse monoclonal

Description

• General description: MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2; two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20 MAP2a appears, at levels equal to that of MAP2b. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in others.
• Specificity: Monoclonal Anti-MAP2 antibody reacts with human, bovine, rat, mouse, Xenopus, salamander, and quail tissue or cells by immunocytochemical techniques utilizing either a fluorescent or peroxidase label, or by immunohistochemistry.
• Immunogen: bovine MAP2
• Application: Monoclonal Anti-MAP2 (2a+2b) antibody produced in mouse has been used in immunocytochemistry.
• Biochem/physiol Actions: Microtubule associated protein 2 (MAP2) is known to promote microtubule assembly and to form side arms on microtubules. It also interacts with neurofilaments, actin and other elements of the cytoskeleton. MAP2 is degraded by a cathepsin D like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in others. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin and other elements of the cytoskeleton.
• Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.