Monoclonal Anti-α-Tubulin antibody produced in mouse

Description

• General description: Monoclonal Anti-α-Tubulin (mouse IgG1 isotype) is derived from the B-5-1-2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Tubulin is the major building block of microtubules.
• Specificity: Monoclonal Anti-alpha-Tubulin antibody recognizes an epitope at the C-terminal end of the α-tubulin isoform in various organisms.
• Immunogen: Sarkosyl-resistant filaments from Strongylocentrotus purpuratus (sea urchin) sperm axonemes.
• Application: Monoclonal Anti-α-Tubulin antibody produced in mouse has been used:In immunofluorescence AnalysisIn western blotting/ ImmunoblottingFor immunolabelling cells in electron microscopy
• Biochem/physiol Actions: Tubulin α 4a (TUBA4A) mutation is associated with amyotrophic lateral sclerosis (ALS). α-Tubulin is a key regulator of cytoskeletal proteins. It mediates cellular developmental stages such as proliferation, migration, signalling and also maintains the shape of the cell. α-Tubulin controls trafficking, signaling and cellular tensegrity mediated by microtubules. The encoded protein is associated with the development and progression of cancer. α-Tubulin acetylation potentiates the metastatic property of breast cancer. Mutation in TUBA4A is associated with the development of various types of cancers, such as oral cancer, breast cancer, rectal cancer, lung cancer and prostate cancer. In addition, variation in the TUBA4A leads to sporadic amyotrophic lateral sclerosis (ALS). Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement and the cytoskeleton.
• Physical form: Liquid
• Storage and Stability: For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
• Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.