SML1658
GSK484
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 1652591-81-5
Synonym(S): ((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride, AOB6992, GSK 484, GSK-484 hydrochloride, GTPL8577
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML1658-5-MG | In Stock | ₹ 41,319.03 |
| 25 MG | SML1658-25-MG | In Stock | ₹ 1,27,117.98 |
SML1658 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 41,319.03
GST (18%): ₹ 7,437.425
Total Price: ₹ 48,756.455
Quality Level
100
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
[H]Cl.CN1C(C2=CC(C=CC=C3)=C3N2CC4CC4)=NC5=C1C(OC)=CC(C(N6C[C@H](N)[C@H](O)CC6)=O)=C5
InChI
1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3;1H/t19-,23+;/m0./s1
InChI key
MULKOGJHUZTANI-ADMBKAPUSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sigma Aldrich Fine Chemicals Biosciences GSK484 >=98% (HPLC) | 1652591-81-5 | 25MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 1,43,364.34 | |
| | eMolecules Medchem Express / GSK484 (hydrochloride) / 5mg / 446255651 / HY-100514 / / 1652591-81-5 / MFCD30343874 / 510.040 / C27H32ClN5O3 | eMolecules | ₹ 23,929.42 | |
 | Cayman Chemical GSK484 (hydrochloride), 1652591-81-5, 5 mg | Cayman Chemical | ₹ 27,845.50 | |
 | Sigma Aldrich Fine Chemicals Biosciences GSK484 | 1652591-81-5 | MFCD30343874 | 5mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 38,256.44 | |
 | Cayman Chemical GSK484 (hydrochloride), 1652591-81-5, 10 mg | Cayman Chemical | ₹ 47,761.30 | |
| | Cayman Chemical GSK484 (hydrochloride), 1652591-81-5, 1 mg | Cayman Chemical | ₹ 6,690.79 | |
 | 1652591-81-5 | GSK484 | A2B Chem | ₹ 5,304.72 - ₹ 77,175.12 |
Related Products
Description
- Biochem/physiol Actions: GSK484 is a potent selective reversible inhibitor of protein arginine deiminase PAD4, an enzyme believed to play a role in granulocyte and macrophage development leading to inflammation and immune response, and overexpressed in many tumors. GSK484 has IC50 values of 50 nM without calcium and 250 nM in the presence of 2 mM calcium. GSK484 showed minimal off-target activity tested against 50 other proteins with no activation across HDACs 1–11 even at 100 μM. GSK484 binds at a different site from the amidines, a conformation of the PAD4 active site where part of the site is reordered to form a β-hairpin. For full characterization details, please visit the GSK484 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
- Features and Benefits: GSK484 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
- Other Notes: GSK484 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GSK484 probe summary on the Chemical Probes Portal website.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: H2O: 2 mg/mL, clear (warmed)
storage temp.: 2-8°C
SMILES string: [H]Cl.CN1C(C2=CC(C=CC=C3)=C3N2CC4CC4)=NC5=C1C(OC)=CC(C(N6C[C@H](N)[C@H](O)CC6)=O)=C5
InChI: 1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3;1H/t19-,23+;/m0./s1
InChI key: MULKOGJHUZTANI-ADMBKAPUSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
H2O: 2 mg/mL, clear (warmed)
storage temp.:
2-8°C
SMILES string:
[H]Cl.CN1C(C2=CC(C=CC=C3)=C3N2CC4CC4)=NC5=C1C(OC)=CC(C(N6C[C@H](N)[C@H](O)CC6)=O)=C5
InChI:
1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3;1H/t19-,23+;/m0./s1
InChI key:
MULKOGJHUZTANI-ADMBKAPUSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 10 mg/mL, clear
storage temp.: 2-8°C
SMILES string: O=C(C1=CC=CN1)N2C[C@@](C(N)=O)(C)C(N(CC3=CC=C(F)C=C3)N=C4C(NC5=CC(C)=C(OC)C(C)=C5)=O)=C4C2
InChI: __
InChI key: __
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 10 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
O=C(C1=CC=CN1)N2C[C@@](C(N)=O)(C)C(N(CC3=CC=C(F)C=C3)N=C4C(NC5=CC(C)=C(OC)C(C)=C5)=O)=C4C2
InChI:
__
InChI key:
__
Quality Level: 200
Assay: __
form: solution
color: __
solubility: __
storage temp.: 2-8°C
SMILES string: __
InChI: 1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
InChI key: __
Quality Level:
200
Assay:
__
form:
solution
color:
__
solubility:
__
storage temp.:
2-8°C
SMILES string:
__
InChI:
1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
InChI key:
__
Quality Level: 200
Assay: __
form: solution
color: __
solubility: __
storage temp.: 2-8°C
SMILES string: __
InChI: 1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
InChI key: __
Quality Level:
200
Assay:
__
form:
solution
color:
__
solubility:
__
storage temp.:
2-8°C
SMILES string:
__
InChI:
1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
InChI key:
__