SML1408
(R)-PFI-2
≥97% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 1627607-87-7
Synonym(S): (R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML1408-5-MG | In Stock | ₹ 18,207.65 |
| 25 MG | SML1408-25-MG | In Stock | ₹ 71,910.48 |
SML1408 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 18,207.65
GST (18%): ₹ 3,277.377
Total Price: ₹ 21,485.027
Quality Level
100
Assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
FC1=C2C(CCNC2)=CC(S(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)(=O)=O)=C1.[H]Cl
InChI
1S/C23H25F4N3O3S.ClH/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27;/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2;1H/t21-;/m1./s1
InChI key
ZADKZNVAJGEFLC-ZMBIFBSDSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sigma Aldrich Fine Chemicals Biosciences (R)-PFI-2 >=97% (HPLC) | 1627607-87-7 | 5MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 22,023.05 | |
| | Sigma Aldrich Fine Chemicals Biosciences (R)-PFI-2 >=97% (HPLC) | 1627607-87-7 | 25MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 83,070.82 | |
 | 1627607-87-7 | PFI-2 hydrochloride | A2B Chem | ₹ 2,047.00 - ₹ 56,604.00 |
Related Products
Description
- Biochem/physiol Actions: (R)-PFI-2 is a histone-lysine N-methyltransferase (HKMT) inhibitor selective for SETD7 (also known as SET9). (R)-PFI-2 has an IC50 value of 2 nM and 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. For full characterization details, please visit the PFI-2 probe summary on the Structural Genomics Consortium (SGC) website.(S)-PFI-2, an enantiomer of (R)-PFI-2, is used as a negative control. (S)-PFI-2 is available from Sigma. To learn more about and purchase (S)-PFI-2, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
- Features and Benefits: (R)-PFI-2 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
- Other Notes: (R)-PFI-2 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the (R)-PFI-2 probe summary on the Chemical Probes Portal website.
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
Quality Level: 100
Assay: ≥97% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 10 mg/mL, clear (warmed)
storage temp.: 2-8°C
SMILES string: FC1=C2C(CCNC2)=CC(S(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)(=O)=O)=C1.[H]Cl
InChI: 1S/C23H25F4N3O3S.ClH/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27;/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2;1H/t21-;/m1./s1
InChI key: ZADKZNVAJGEFLC-ZMBIFBSDSA-N
Quality Level:
100
Assay:
≥97% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 10 mg/mL, clear (warmed)
storage temp.:
2-8°C
SMILES string:
FC1=C2C(CCNC2)=CC(S(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)(=O)=O)=C1.[H]Cl
InChI:
1S/C23H25F4N3O3S.ClH/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27;/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2;1H/t21-;/m1./s1
InChI key:
ZADKZNVAJGEFLC-ZMBIFBSDSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 10 mg/mL, clear
storage temp.: 2-8°C
SMILES string: NC1=NC2=CC(OCCCN3CCCC3)=C(OC)C=C2C14CCC4
InChI: 1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
InChI key: BKCDJTRMYWSXMC-UHFFFAOYSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 10 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
NC1=NC2=CC(OCCCN3CCCC3)=C(OC)C=C2C14CCC4
InChI:
1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
InChI key:
BKCDJTRMYWSXMC-UHFFFAOYSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 20 mg/mL, clear
storage temp.: 2-8°C
SMILES string: O=S(NC1=CC=C(N(C)C(C(C)=C2)=O)C2=C1)(C3=C(OC)C=C(C#N)C=C3)=O
InChI: 1S/C19H17N3O4S/c1-12-8-14-10-15(5-6-16(14)22(2)19(12)23)21-27(24,25)18-7-4-13(11-20)9-17(18)26-3/h4-10,21H,1-3H3
InChI key: UEMQPCYDWCSVCU-UHFFFAOYSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 20 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
O=S(NC1=CC=C(N(C)C(C(C)=C2)=O)C2=C1)(C3=C(OC)C=C(C#N)C=C3)=O
InChI:
1S/C19H17N3O4S/c1-12-8-14-10-15(5-6-16(14)22(2)19(12)23)21-27(24,25)18-7-4-13(11-20)9-17(18)26-3/h4-10,21H,1-3H3
InChI key:
UEMQPCYDWCSVCU-UHFFFAOYSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 20 mg/mL, clear
storage temp.: 2-8°C
SMILES string: O=C(OC(C)(C)C)C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1
InChI: 1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
InChI key: DNVXATUJJDPFDM-KRWDZBQOSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 20 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
O=C(OC(C)(C)C)C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1
InChI:
1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
InChI key:
DNVXATUJJDPFDM-KRWDZBQOSA-N