SML0701
GSK-J4
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 1373423-53-0
Synonym(S): Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML0701-5-MG | In Stock | ₹ 13,453.20 |
| 25 MG | SML0701-25-MG | In Stock | ₹ 54,767.40 |
SML0701 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 13,453.20
GST (18%): ₹ 2,421.576
Total Price: ₹ 15,874.776
Quality Level
100
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(OCC)CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CC=N4)=N1
InChI
1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)
InChI key
WBKCKEHGXNWYMO-UHFFFAOYSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-15648B 50mg , GSK-J4 CAS:1373423-53-0 Purity:>98% | Medchemexpress LLC | ₹ 41,505.16 | |
 | Sigma Aldrich Fine Chemicals Biosciences GSK-J4 | 1373423-53-0 | MFCD22683852 | 5mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 12,577.32 | |
 | eMolecules Medchem Express / GSK-J4 / 10mg / 446266240 / HY-15648B / / 1373423-53-0 / MFCD22683852 / 417.513 / C24H27N5O2 | eMolecules | ₹ 19,899.54 | |
 | Apexbio Technology LLC ethyl ester GSK-J1 derivative 1373423-53-0. MFCD26142638 | Apexbio Technology LLC | ₹ 9,411.60 | |
| | Sigma Aldrich Fine Chemicals Biosciences GSK-J4 >=98% (HPLC) | 1373423-53-0 | MFCD22683852 | 25MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 49,487.90 | |
 | 1373423-53-0 | Gsk-j4 | A2B Chem | ₹ 855.60 - ₹ 1,13,709.24 |
Related Products
Description
- Application: GSK-J4 has been used to study the effect of KDM2B (Jumonji (JmjC) domain histone 3 lysine 36 (H3K36) di-demethylase) inhibition on the survival and DNA repair potential of glioblastoma cells.[1] It has also been used in sulforhodamine B (SRB) cell growth assay and cell viability assay.[2][3]
- Biochem/physiol Actions: GSK-J4 is cell permeable prodrug rapidly hydrolysed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor. Jumonji C domain-containing histone demethylases (JHDMs) are Fe(II) and α-ketoglutarate dependent enzymes that oxygenate methylated histone lysine residues and thereby cause their demethylation. GSK-J1 is selective for the KDM6 subfamily members JMJD3 and UTX with an IC50 of 60 nM in a JMJD3 assay, and is inactive against other demethylases of the JMJ family and over 100 tested kinases and histone deacetylases. The prodrug GSK-J4 inhibited TNF-α production with an IC50 of 9 μM in LPS-stimulated human macrophages and blocked the production of TNF-α by macrophages derived from patients with rheumatoid arthritis. For characterization details for GSK-J4 and full characterization details for GSK-J1, please visit the GSK-J1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
- Features and Benefits: GSK-J4 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
- Other Notes: GSK-J4 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GSK-J4 probe summary on the Chemical Probes Portal website.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
storage condition: desiccated
color: white to beige
solubility: DMSO: 20 mg/mL, clear
storage temp.: 2-8°C
SMILES string: O=C(OCC)CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CC=N4)=N1
InChI: 1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)
InChI key: WBKCKEHGXNWYMO-UHFFFAOYSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
storage condition:
desiccated
color:
white to beige
solubility:
DMSO: 20 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
O=C(OCC)CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CC=N4)=N1
InChI:
1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)
InChI key:
WBKCKEHGXNWYMO-UHFFFAOYSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
storage condition: __
color: white to beige
solubility: DMSO: 15 mg/mL, clear
storage temp.: 2-8°C
SMILES string: OC(CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CC=N4)=N1)=O
InChI: 1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26)
InChI key: AVZCPICCWKMZDT-UHFFFAOYSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
storage condition:
__
color:
white to beige
solubility:
DMSO: 15 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
OC(CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CC=N4)=N1)=O
InChI:
1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26)
InChI key:
AVZCPICCWKMZDT-UHFFFAOYSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
storage condition: __
color: white to beige
solubility: DMSO: 15 mg/mL, clear
storage temp.: 2-8°C
SMILES string: CC(C)N1CCN(C2=NC=C(C3=CC4=C(C=NN4C(C)C)C(C(NCC5=C(CCC)C=C(C)NC5=O)=O)=C3)C=C2)CC1
InChI: 1S/C33H43N7O2/c1-7-8-24-15-23(6)37-33(42)28(24)19-35-32(41)27-16-26(17-30-29(27)20-36-40(30)22(4)5)25-9-10-31(34-18-25)39-13-11-38(12-14-39)21(2)3/h9-10,15-18,20-22H,7-8,11-14,19H2,1-6H3,(H,35,41)(H,37,42)
InChI key: DPJNKUOXBZSZAI-UHFFFAOYSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
storage condition:
__
color:
white to beige
solubility:
DMSO: 15 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
CC(C)N1CCN(C2=NC=C(C3=CC4=C(C=NN4C(C)C)C(C(NCC5=C(CCC)C=C(C)NC5=O)=O)=C3)C=C2)CC1
InChI:
1S/C33H43N7O2/c1-7-8-24-15-23(6)37-33(42)28(24)19-35-32(41)27-16-26(17-30-29(27)20-36-40(30)22(4)5)25-9-10-31(34-18-25)39-13-11-38(12-14-39)21(2)3/h9-10,15-18,20-22H,7-8,11-14,19H2,1-6H3,(H,35,41)(H,37,42)
InChI key:
DPJNKUOXBZSZAI-UHFFFAOYSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
storage condition: __
color: yellow to orange
solubility: DMSO: 10 mg/mL, clear
storage temp.: 2-8°C
SMILES string: OC1=C(C(/C=C/N2[C@H](C3)CN(C4=NC=CC=C4)[C@H]3C2)=O)C=CC=C1
InChI: 1S/C19H19N3O2/c23-17-6-2-1-5-16(17)18(24)8-10-21-12-15-11-14(21)13-22(15)19-7-3-4-9-20-19/h1-10,14-15,23H,11-13H2/b10-8+/t14-,15-/m1/s1
InChI key: INAICWLVUAKEPB-QSTFCLMHSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
storage condition:
__
color:
yellow to orange
solubility:
DMSO: 10 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
OC1=C(C(/C=C/N2[C@H](C3)CN(C4=NC=CC=C4)[C@H]3C2)=O)C=CC=C1
InChI:
1S/C19H19N3O2/c23-17-6-2-1-5-16(17)18(24)8-10-21-12-15-11-14(21)13-22(15)19-7-3-4-9-20-19/h1-10,14-15,23H,11-13H2/b10-8+/t14-,15-/m1/s1
InChI key:
INAICWLVUAKEPB-QSTFCLMHSA-N