SML1242

SGC707

≥98% (HPLC)

Manufacturer: Sigma Aldrich

CAS Number: 1687736-54-4

Synonym(S): 1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea

Select a Size

Pack Size SKU Availability Price
5 MG SML1242-5-MG In Stock ₹ 12,459.58
25 MG SML1242-25-MG In Stock ₹ 39,792.70

SML1242 - 5 MG

₹ 12,459.58

In Stock

Quantity

1

Base Price: ₹ 12,459.58

GST (18%): ₹ 2,242.724

Total Price: ₹ 14,702.304

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2

InChI

1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)

InChI key

DMIDPTCQPIJYFE-UHFFFAOYSA-N

Other Options

Image Product Name Manufacturer Price Range
AR001YYW
N-6-Isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea
Aaron Chemicals LLC ₹ 1,602.00 - ₹ 14,952.00

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Description

  • Biochem/physiol Actions: SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 has an IC50 value of 50 nM and >100-fold selectivity over other methyltransferases and non-epigenetic targets. SGC707 binds to PRMT3 with KD of 50 nM (ITC), and inhibits histone methylation in cells with an IC50 value below 1 μM. For full characterization details, please visit the SGC707 probe summary on the Structural Genomics Consortium (SGC) website.XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
  • Features and Benefits: SGC707 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
  • Other Notes: SGC707 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the SGC707 probe summary on the Chemical Probes Portal website.

SAFETY INFORMATION

Pictograms

GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Quality Level:
100

Assay:
≥98% (HPLC)

form:
powder

color:
white to light brown

solubility:
DMSO: 20 mg/mL, clear

storage temp.:
2-8°C

SMILES string:
O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2

InChI:
1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)

InChI key:
DMIDPTCQPIJYFE-UHFFFAOYSA-N

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__

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__

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__

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__

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1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1

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__

Img

Sigma Aldrich

SML1278

1 mg/mL, from Streptomyces hygrosco...


Quality Level:
200

Assay:
__

form:
DMSO solution

color:
__

solubility:
__

storage temp.:
−20°C

SMILES string:
__

InChI:
1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1

InChI key:
__