SML1979
FM-381
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 2226521-65-7
Synonym(S): (E)-2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide, 2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML1979-5-MG | In Stock | ₹ 16,107.60 |
| 25 MG | SML1979-25-MG | In Stock | ₹ 62,038.08 |
SML1979 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 16,107.60
GST (18%): ₹ 2,899.368
Total Price: ₹ 19,006.968
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
CN(C(/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5)=O)C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Selleck Chemical LLC FM-381 2mg 2226521-65-7 | Selleck Chemical LLC | ₹ 15,092.78 | |
 | eMolecules Ambeed / 2-Cyano-3-(5-(1-cyclohexyl-16-dihydroimidazo[45-d]pyrrolo[23-b]pyridin-2-yl)furan-2-yl)-NN-dimethylacrylamide / 1mg / 761012828 / A955503 / / 2226521-65-7 / [null] / 428.496 / C24H24N6O2 | eMolecules | ₹ 6,045.67 | |
 | 2226521-65-7 | FM381 | A2B Chem | ₹ 3,422.40 - ₹ 22,331.16 |
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Description
- Biochem/physiol Actions: FM-381 is a highly potent and JAK3-selective janus kinase (JAK) inhibitor (IC50 = 127 pM/JAK3, 52 nM/JAK1, 346 nM/JAK2, 459 nM/TYK2 by radiometric assay; [ATP] = 10 μM) that targets JAK3 gatekeeper (GK) Cys909 for a reversible covalent interaction, exhibiting much reduced or little potency against a panel of 409 other kinases. FM-381 is >3-fold more potent than the JAK1/3 inhibitor Tofacitinib (IC50 = 292 pM/JAK3, 496 pM/JAK1, 2.2 nM/JAK2, 8.9 nM/TYK2 by radiometric assay; [ATP] = 10 μM) in blocking JAK1/JAK3-mediated STAT5 phosphorylation in human CD4+ T-cells upon IL-2 stimulation (ECmax ∼100 nM with FM-381), while being ineffective (up to 1 μM) against JAK3-independent STAT1/3 phosphorylation following IL-6 or TNFα stimulation. For characterization details of FM-381, please visit the FM-381 probe summary on the Structural Genomics Consortium (SGC) website.FM-479 is the negative control for the active probe, FM-381. FM-479 is available from Sigma. To learn more about and purchase FM-479, click here.To learn about other SGC chemical probes, visit sigma.com/sgc
- Features and Benefits: FM-381 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 2 mg/mL, clear (warmed)
storage temp.: 2-8°C
SMILES string: CN(C(/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5)=O)C
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 2 mg/mL, clear (warmed)
storage temp.:
2-8°C
SMILES string:
CN(C(/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5)=O)C
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 2 mg/mL, clear (warmed)
storage temp.: −20°C
SMILES string: O=C1N(C)C2=CC(N3CCNC[C@H]3C)=C(N(CC)C(C4=C(OC)C=CC=C4)=O)C=C2N1C
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 2 mg/mL, clear (warmed)
storage temp.:
−20°C
SMILES string:
O=C1N(C)C2=CC(N3CCNC[C@H]3C)=C(N(CC)C(C4=C(OC)C=CC=C4)=O)C=C2N1C
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 2 mg/mL, clear
storage temp.: −20°C
SMILES string: O=C1N(C)C2=CC(N3CCNC[C@H]3C)=C(NC(C4=C(OC)C=CC=C4)=O)C=C2N1C
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 2 mg/mL, clear
storage temp.:
−20°C
SMILES string:
O=C1N(C)C2=CC(N3CCNC[C@H]3C)=C(NC(C4=C(OC)C=CC=C4)=O)C=C2N1C
Assay: ≥98% (HPLC)
form: powder
color: yellow to orange
solubility: DMSO: 2 mg/mL, clear
storage temp.: 2-8°C
SMILES string: CN(C(/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(N(C)C=C4)C4=C3N2C5CCCCC5)=O)C
Assay:
≥98% (HPLC)
form:
powder
color:
yellow to orange
solubility:
DMSO: 2 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
CN(C(/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(N(C)C=C4)C4=C3N2C5CCCCC5)=O)C