SGC3027
≥98 mg/mL (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 2624313-13-7
Synonym(S): SGC3027, 5′-S-[4-[(N-(3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl)butyryl)-(N-(4′-chloro-biphenyl-3-ylmethyl)amino]butyl]-5′-thioadenosine, N-(4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butyl)-N-((4′-chloro-[1,1′-biphenyl]-3-yl)methyl)-3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML2343-5-MG | In Stock | ₹ 20,729.88 |
| 25 MG | SML2343-25-MG | In Stock | ₹ 83,265.90 |
SML2343 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 20,729.88
GST (18%): ₹ 3,731.378
Total Price: ₹ 24,461.258
form
powder
concentration
≥98 mg/mL (HPLC)
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
ClC(C=C1)=CC=C1C2=CC(CN(C(CC(C)(C)C(C(C(C)=C3C)=O)=C(C)C3=O)=O)CCCCSC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H](O)[C@@H]4O)=CC=C2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | 2624313-13-7 | SGC3027 | A2B Chem | ₹ 4,705.80 - ₹ 24,812.40 |
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Description
- Biochem/physiol Actions: SGC3027 is a selective and cell-active inhibitor of protein arginine N-methyltransferase (PRMT7) It is a pro-drug of the active component, SGC8158, which is produced in the cell by reductases. SGC8158 was shown to inhibit PRMT7 with an IC50 value < 2.5 nM for methylation of H2B (23-37) and greater than 40-fold selectivity over other histone methyltransferases and non-epigenetic targets. SGC3027 inhibited the methylation of HSP70 In cellular assays using C2C12 cells with an IC50 value of 1.3 microM. The closely related SGC3027N is significantly less active in the cellular assay, and is a control compound for cellular studies.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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form: powder
concentration: ≥98 mg/mL (HPLC)
color: white to beige
solubility: DMSO: 2 mg/mL, clear
storage temp.: −20°C
SMILES string: ClC(C=C1)=CC=C1C2=CC(CN(C(CC(C)(C)C(C(C(C)=C3C)=O)=C(C)C3=O)=O)CCCCSC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H](O)[C@@H]4O)=CC=C2
form: powder
concentration: __
color: white to beige
solubility: DMSO: 2 mg/mL, clear
storage temp.: −20°C
SMILES string: O=C(N1C)N(C)C2=C1C=C(OC3=CC=CC(OCCC)=C3)C(NS(C4=CC(C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)=CC=C4)(=O)=O)=C2
form: powder
concentration: __
color: white to beige
solubility: H2O: 2 mg/mL, clear
storage temp.: −20°C
SMILES string: __
