01-674-638
HPK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-674-638-Each-of-1 | In Stock | ₹ 44,191.74 |
01-674-638 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,191.74
GST (18%): ₹ 7,954.513
Total Price: ₹ 52,146.253
Antigen
HPK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MAP4K1
Gene Alias
EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
11184
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q92918
Gene Symbols
MAP4K1
Immunogen
Synthetic peptide corresponding to the N terminus amino acids DVVDPDIFNRDPR.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000
- MAP4K1 (also known as HPK1) or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family
- MAP4K1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway
- MAP4K1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76
- The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells
- The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation
- We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predominantly in hematopoietic cells, including early progenitor cells
- HPK1 is related distantly to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade
- Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo
- HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a dominant-negative MEKK1 or MKK4/SEK mutant
- Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1.
Compare Similar Items
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Antigen: HPK1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MAP4K1
Gene Alias: EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species: Goat
Purification Method: Ammonium sulfate precipitation
Regulatory Status: RUO
Gene ID (Entrez): 11184
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.5 mg/mL
Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q92918
Gene Symbols: MAP4K1
Immunogen: Synthetic peptide corresponding to the N terminus amino acids DVVDPDIFNRDPR.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
HPK1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MAP4K1
Gene Alias:
EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species:
Goat
Purification Method:
Ammonium sulfate precipitation
Regulatory Status:
RUO
Gene ID (Entrez):
11184
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.5 mg/mL
Formulation:
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q92918
Gene Symbols:
MAP4K1
Immunogen:
Synthetic peptide corresponding to the N terminus amino acids DVVDPDIFNRDPR.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: IRF8
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Irf8
Gene Alias: AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
Host Species: Goat
Purification Method: Ammonium sulfate precipitation
Regulatory Status: RUO
Gene ID (Entrez): 3394
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry, Western Blot
Concentration: 0.5 mg/mL
Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q02556
Gene Symbols: Irf8
Immunogen: Synthetic peptide corresponding to the C terminus amino acids QRSFFRENQQITV.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
IRF8
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Irf8
Gene Alias:
AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
Host Species:
Goat
Purification Method:
Ammonium sulfate precipitation
Regulatory Status:
RUO
Gene ID (Entrez):
3394
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry, Western Blot
Concentration:
0.5 mg/mL
Formulation:
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q02556
Gene Symbols:
Irf8
Immunogen:
Synthetic peptide corresponding to the C terminus amino acids QRSFFRENQQITV.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: IRAK4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: IRAK4
Gene Alias: 8430405M07Rik; 9330209D03Rik; interleukin 1 receptor associated kinase 4; interleukin-1; interleukin-1 receptor-associated kinase 4; IPD1; Irak4; IRAK-4; NY-REN-64; REN64; renal carcinoma antigen NY-REN-64
Host Species: Goat
Purification Method: Ammonium sulfate precipitation
Regulatory Status: RUO
Gene ID (Entrez): 51135
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: 0.5 mg/mL
Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q9NWZ3
Gene Symbols: IRAK4
Immunogen: Synthetic peptide corresponding to the N terminus amino acids NKPITPSTYVRC.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
IRAK4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
IRAK4
Gene Alias:
8430405M07Rik; 9330209D03Rik; interleukin 1 receptor associated kinase 4; interleukin-1; interleukin-1 receptor-associated kinase 4; IPD1; Irak4; IRAK-4; NY-REN-64; REN64; renal carcinoma antigen NY-REN-64
Host Species:
Goat
Purification Method:
Ammonium sulfate precipitation
Regulatory Status:
RUO
Gene ID (Entrez):
51135
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
0.5 mg/mL
Formulation:
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q9NWZ3
Gene Symbols:
IRAK4
Immunogen:
Synthetic peptide corresponding to the N terminus amino acids NKPITPSTYVRC.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: IRF5
Classification: Polyclonal
Conjugate: Unconjugated
Gene: IRF5
Gene Alias: AW491843; Interferon regulatory factor 5; interferon regulatory factor 5 bone marrow; IRF5; IRF-5; mirf5; OTTHUMP00000212907; SLEB10
Host Species: Goat
Purification Method: Ammonium sulfate precipitation
Regulatory Status: RUO
Gene ID (Entrez): 3663
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.5 mg/mL
Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q13568
Gene Symbols: IRF5
Immunogen: Synthetic peptide corresponding to the C terminus amino acids QGPWPMHPAGMQ.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
IRF5
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
IRF5
Gene Alias:
AW491843; Interferon regulatory factor 5; interferon regulatory factor 5 bone marrow; IRF5; IRF-5; mirf5; OTTHUMP00000212907; SLEB10
Host Species:
Goat
Purification Method:
Ammonium sulfate precipitation
Regulatory Status:
RUO
Gene ID (Entrez):
3663
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.5 mg/mL
Formulation:
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q13568
Gene Symbols:
IRF5
Immunogen:
Synthetic peptide corresponding to the C terminus amino acids QGPWPMHPAGMQ.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG