01-676-016

IGF2R Monoclonal Antibody (MEM-238), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 01-676-016-Each-of-1 In Stock ₹ 37,817.52

01-676-016 - Each of 1

₹ 37,817.52

In Stock

Quantity

1

Base Price: ₹ 37,817.52

GST (18%): ₹ 6,807.154

Total Price: ₹ 44,624.674

Antigen

IGF2R

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with 15mM sodium azide; pH 7.4

Gene Accession No.

P11717

Gene Symbols

IGF2R

Immunogen

Recombinant Vaccinia virus encoding CD222.

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human, Non-human Primate

Product Type

Antibody

Isotype

IgG1

Applications

Flow Cytometry, Immunoprecipitation, Western Blot

Clone

MEM-238

Conjugate

Unconjugated

Gene

IGF2R

Gene Alias

300 kDa mannose 6-phosphate receptor; AI661837; cation-independent mannose 6-phosphate receptor; cation-independent mannose 6-phosphate receptor protein; cation-independent mannose-6-phosphate receptor; cation-independent MPR; CD222; CI Man-6-P receptor; CI-M6PR; CIMPR; CI-MPR; Igf2r; IGF-II receptor; IGF-II/CI-MPR; Igfr2; insulin like growth factor 2 receptor; insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; insulin-like growth factor receptor type 2; M6P; M6P/IGF2 receptor; M6P/IGF2R; M6PR; M6P-R; mannose-6-phosphate receptor, cation independent; mannose-6-phosphate/insulin-like growth factor II receptor; MPR 300; MPR1; MPR300; MPRI; similar to mannose-6-phosphate/insulin-like growth factor II receptor

Host Species

Mouse

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

3482

Content And Storage

4° C, do not freeze

Form

Liquid

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Description

  • This antibody recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein
  • The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum
  • Western blot should be performed under non-reducing conditions
  • Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of approximately 300 kDa cation independent mannose 6-phospate receptors (CI-MPR)
  • The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes
  • The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes
  • The entire pool of MPRs cycles between these cellular compartments every 3 hours
  • The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and approximately 10 % at cell surface
  • In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously
  • An approximately 240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.

Compare Similar Items

Show Difference

Img

Thermo Scientific

01-676-016

--


Antigen:
IGF2R

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 15mM sodium azide; pH 7.4

Gene Accession No.:
P11717

Gene Symbols:
IGF2R

Immunogen:
Recombinant Vaccinia virus encoding CD222.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Non-human Primate

Product Type:
Antibody

Isotype:
IgG1

Applications:
Flow Cytometry, Immunoprecipitation, Western Blot

Clone:
MEM-238

Conjugate:
Unconjugated

Gene:
IGF2R

Gene Alias:
300 kDa mannose 6-phosphate receptor; AI661837; cation-independent mannose 6-phosphate receptor; cation-independent mannose 6-phosphate receptor protein; cation-independent mannose-6-phosphate receptor; cation-independent MPR; CD222; CI Man-6-P receptor; CI-M6PR; CIMPR; CI-MPR; Igf2r; IGF-II receptor; IGF-II/CI-MPR; Igfr2; insulin like growth factor 2 receptor; insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; insulin-like growth factor receptor type 2; M6P; M6P/IGF2 receptor; M6P/IGF2R; M6PR; M6P-R; mannose-6-phosphate receptor, cation independent; mannose-6-phosphate/insulin-like growth factor II receptor; MPR 300; MPR1; MPR300; MPRI; similar to mannose-6-phosphate/insulin-like growth factor II receptor

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
3482

Content And Storage:
4° C, do not freeze

Form:
Liquid

Img

Thermo Scientific

01-676-021

--


Antigen:
Herpes Simplex Virus Type 1/2 gB

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 15mM sodium azide; pH 7.4

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
Exctract of HSV-1 infected VERO cells..

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Virus

Product Type:
Antibody

Isotype:
IgG2b

Applications:
ELISA, Immunocytochemistry

Clone:
T111

Conjugate:
Unconjugated

Gene:
__

Gene Alias:
Herpes Simplex 1; Herpes Simplex 2; Herpes Simplex I; Herpes Simplex II; HHV; HHV-2; HSV; HSV 1/2; HSV I/II; HSV Type 1; HSV Type 2; HSV Type II; HSV1; HSV2; HSV-2

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
__

Content And Storage:
4° C, do not freeze

Form:
Liquid

Img

Thermo Scientific

01-676-023

--


Antigen:
HSV Type 1 gC

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 15mM sodium azide; pH 7.4

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
Exctract of HSV-1 infected VERO cells..

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Virus

Product Type:
Antibody

Isotype:
IgG2b

Applications:
ELISA, Immunocytochemistry, Western Blot

Clone:
T96

Conjugate:
Unconjugated

Gene:
__

Gene Alias:
Herpes Simplex 1; Herpes Simplex I; herpes simplex virus 1 gc; HHV; HSV; HSV Type 1; HSV1

Host Species:
Mouse

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
__

Content And Storage:
4° C, do not freeze

Form:
Liquid

Img

Thermo Scientific

01-676-025

--


Antigen:
HSV Type 2

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 15mM sodium azide; pH 7.4

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
Exctract of HSV-2 infected VERO (green monkey kidney) cells.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Virus

Product Type:
Antibody

Isotype:
IgG2a

Applications:
ELISA, Immunocytochemistry, Western Blot

Clone:
T303

Conjugate:
Unconjugated

Gene:
__

Gene Alias:
Herpes Simplex 2; Herpes Simplex II; herpes simplex virus 2; HHV-2; HSV Type 2; HSV Type II; HSV2; HSV-2

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
__

Content And Storage:
4° C, do not freeze

Form:
Liquid