14-788-882
IRF8 Monoclonal Antibody (GW4CML3), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-788-882-Each-of-1 | In Stock | ₹ 24,983.52 |
14-788-882 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 24,983.52
GST (18%): ₹ 4,497.034
Total Price: ₹ 29,480.554
Antigen
IRF8
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P23611, Q02556
Gene Symbols
Irf8
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
15900, 3394
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry, Western Blot
Clone
GW4CML3
Conjugate
Unconjugated
Gene
Irf8
Gene Alias
AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: The GW4CML3 monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP)
- IRF8 is a 50 kDa transcription factor that plays a critical role in the development of dendritic cells (DC)
- Specifically, IRF8 is essential in the development and differentiation of plasmacytoid DC (pDC) and CD8a+ DC
- IRF8-/- mice are deficient in both pDC and CD8a+ DC populations
- CD8a- DC are present in normal numbers in IRF8-/- mice but fail to mature upon Toll-like receptor signaling and are functionally impaired in response to in vivo microbial stimulation
- IRF8 deficiency does not affect the frequency or viability of DC precursors and as a result retroviral IRF8 transduction restores pDC development from DC progenitors in IRF8-/- mice
- Applications Reported: This GW4CML3 antibody has been reported for use in intracellular staining followed by flow cytometric analysis, and western blotting
- (Fluorochrome conjugated GW4CML3 is recommended for use in intracellular flow cytometry)
- Applications Tested: This GW4CML3 antibody has been tested by western blot on lysates from stimulated normal human peripheral blood cells
- This can be used at 1-5 μg/mL
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor
- It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes
- IRF8 plays a negative regulatory role in cells of the immune system
- It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells
- This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes
- Mutations in the gene can result in immunodeficiencey 32A and 32B.
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Antigen: IRF8
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P23611, Q02556
Gene Symbols: Irf8
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 15900, 3394
Content And Storage: 4° C
Form: Liquid
Applications: Flow Cytometry, Western Blot
Clone: GW4CML3
Conjugate: Unconjugated
Gene: Irf8
Gene Alias: AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
IRF8
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P23611, Q02556
Gene Symbols:
Irf8
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
15900, 3394
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Western Blot
Clone:
GW4CML3
Conjugate:
Unconjugated
Gene:
Irf8
Gene Alias:
AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG1 κ
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