14-974-937
APP (Amyloid Precursor Protein) Monoclonal Antibody (22C11), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-974-937-Each-of-1 | In Stock | ₹ 1,17,388.32 |
14-974-937 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,17,388.32
GST (18%): ₹ 21,129.898
Total Price: ₹ 1,38,518.218
Antigen
APP (Amyloid Precursor Protein)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P05067, P08592, P12023
Gene Symbols
APP
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11820, 351, 54226
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Clone
22C11
Conjugate
Unconjugated
Gene
APP
Gene Alias
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid A4; Amyloid b precursor protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; Amyloid β precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
Host Species
Mouse
Quantity
2 mg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- The MAb 22C11 recognizes human, mouse, and rat APP (Amyloid Precursor Protein)
- APP is expressed in high abundance in the central nervous system and has three major isoforms resulting from alternative splicing
- APP plays a role in synaptic formation and repair, anterograde neuronal transport, iron export, and hormonal regulation
- Secreted APP (sAPP) may have neuroprotective effects against neurotoxic insult, oxidative stress, and excitotoxicity
- APP belongs to a family that contains at least two homologs, amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2)
- Similarities between APP and APLP, especially APLP2, suggest that APLP could share and compensate for the function of APP
- Proteolytic cleavage of APP results in the generation of beta amyloid, which is the primary component of senile plaques
- Senile plaques are one of the major histopathologic features of Alzheimer's disease
- Abnormal regulation and processing of APP also plays a role in Down's syndrome, early onset familial Alzheimer's disease, cerebral hemorrhage, and arthritis
- This 22C11 antibody reacts with pre-A4 and recognizes all three isoforms of APP (immature, sAPP, and mature)
- This 22C11 antibody is known to cross react with APLP2
- Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1
- APP is important for neurite growth, neuronal adhesion and axonogenesis
- APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing
- Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques
- Senile plaques are one of the major histopathologic features of Alzheimer's disease
- Abnormal regulation and processing of APP also plays a role in Down's syndrome, early onset familial Alzheimer's disease, and cerebral hemorrhage.
Compare Similar Items
Show Difference
Antigen: APP (Amyloid Precursor Protein)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P05067, P08592, P12023
Gene Symbols: APP
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11820, 351, 54226
Content And Storage: 4° C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Clone: 22C11
Conjugate: Unconjugated
Gene: APP
Gene Alias: A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid A4; Amyloid b precursor protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; Amyloid β precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
Host Species: Mouse
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
APP (Amyloid Precursor Protein)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P05067, P08592, P12023
Gene Symbols:
APP
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11820, 351, 54226
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Clone:
22C11
Conjugate:
Unconjugated
Gene:
APP
Gene Alias:
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid A4; Amyloid b precursor protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; Amyloid β precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: IDO
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P14902
Gene Symbols: Ido1
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 3620
Content And Storage: 4° C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: V1NC3IDO
Conjugate: Unconjugated
Gene: Ido1
Gene Alias: EC 1.13.11.52; IDO; IDO1; IDO-1; INDO; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine; indoleamine 2,3-dioxygenase 1; indoleamine 23-dioxygenase; Indoleamine-2; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase
Host Species: Mouse
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2b κ
Antigen:
IDO
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P14902
Gene Symbols:
Ido1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3620
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
V1NC3IDO
Conjugate:
Unconjugated
Gene:
Ido1
Gene Alias:
EC 1.13.11.52; IDO; IDO1; IDO-1; INDO; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine; indoleamine 2,3-dioxygenase 1; indoleamine 23-dioxygenase; Indoleamine-2; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2b κ
Antigen: Somatostatin
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P60041, P60042, P61278
Gene Symbols: SST
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20604, 24797, 6750
Content And Storage: 4° C
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Clone: ICDCLS
Conjugate: Unconjugated
Gene: SST
Gene Alias: Antrin; Growth hormone release-inhibiting factor; Neuronostatin; NST; preprosomatostatin; prepro-somatostatin; SMST; SOM; Somatostatin; somatostatin 28; somatostatin-14; Somatostatin-28; somatotropin release-inhibiting factor; SRIF; SS; SS-14; SS-28; Sst; SST-14
Host Species: Mouse
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
Somatostatin
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P60041, P60042, P61278
Gene Symbols:
SST
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20604, 24797, 6750
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Clone:
ICDCLS
Conjugate:
Unconjugated
Gene:
SST
Gene Alias:
Antrin; Growth hormone release-inhibiting factor; Neuronostatin; NST; preprosomatostatin; prepro-somatostatin; SMST; SOM; Somatostatin; somatostatin 28; somatostatin-14; Somatostatin-28; somatotropin release-inhibiting factor; SRIF; SS; SS-14; SS-28; Sst; SST-14
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: ErbB2 (HER-2)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P04626
Gene Symbols: ERBB2
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 2064
Content And Storage: 4° C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: MJD2
Conjugate: Unconjugated
Gene: ERBB2
Gene Alias: avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); CD antigen CD340; CD340; c-erb B2/neu protein; c-erbB2; C-erbB-2; c-neu; epidermal growth factor receptor-related protein; erbb 2; ERBB2; erb-b2; Erbb-2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; erb-b2 receptor tyrosine kinase 2; her 2; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; Kiaa3023; metas; Metastatic lymph node gene 19 protein; mKIAA3023; MLN 19; MLN19; NEU; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Host Species: Mouse
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
ErbB2 (HER-2)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P04626
Gene Symbols:
ERBB2
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
2064
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
MJD2
Conjugate:
Unconjugated
Gene:
ERBB2
Gene Alias:
avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); CD antigen CD340; CD340; c-erb B2/neu protein; c-erbB2; C-erbB-2; c-neu; epidermal growth factor receptor-related protein; erbb 2; ERBB2; erb-b2; Erbb-2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; erb-b2 receptor tyrosine kinase 2; her 2; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; Kiaa3023; metas; Metastatic lymph node gene 19 protein; mKIAA3023; MLN 19; MLN19; NEU; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ