CD85k (ILT3) Monoclonal Antibody (ZM4.1), Functional Grade, eBioscience™, Invitrogen™

Description

• The MAb ZM4.1 recognizes ILT3, also known as CD85k
• ILT3 is a member of the large family of ILT molecules (Immunologulin-like Transcripts, Leucocyte Ig-like Receptors (LIRs) and Monocyte/Macrophage Ig-like Receptors (MIRs)
• ILT3 is a 60kDa transmembrane protein with two Ig domains and ITIMs
• Expression is found on monocytes, macrophages, and dendritic cells
• High levels of ILT3 expression is also found on plasmacytoid dendritic cells (pDCs)
• ILT3 expression by DCs has been shown to be required to induce Regulatory Tcells (tregs)
• Addition of ZM4.1, like ZM3.8, blocks the suppressive function of the Tregs in in vitro culture systems with allogenic DC's
• This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4
• The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs)
• The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response
• The receptor can also function in antigen capture and presentation
• It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity
• Multiple transcript variants encoding different isoforms have been found for this gene
• [provided by RefSeq, Jul 2008].