CD66b Monoclonal Antibody (G10F5), PE-Cyanine7, eBioscience™, Invitrogen™

Description

• This G10F5 MAb reacts with human CD66b, one of four members of the CD66 family of granulocyte-specific activation antigens
• Expressed on neutrophils and eosinophils, CD66b is upregulated following stimulation
• This glycosyl-phosphatidylinositol-linked cell surface receptor plays a role in regulating neutrophil activation and adhesion to fibronectin, galectin-3, and E-selectin
• This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily
• Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19
• Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster
• The encoded protein was originally described in bile ducts of liver as biliary glycoprotein
• Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia
• The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup
• Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses
• Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.