IgE Monoclonal Antibody (Ige21), PE-Cyanine7, eBioscience™, Invitrogen™

Description

• The MAb IgE21 recognizes the immunoglobulin E class of antibodies
• The natural levels of IgE in the serum are quite low, comprising only a small portion of the total immunoglobulin
• IgE plays a role in allergy responses by binding to mast cells and basophils through the Fc epsilon receptor I which results in the release of histamine and other molecules
• The IgE is produced by terminally differentiated plasma B cells and basophils
• Like all immunoglobulins, IgE is expressed as a soluble molecule as well as a membrane bound form
• IgE21 recognizes both forms
• IgE is one of the five classes of immunoglobulins found in mammals
• Monomers consist of two heavy (epsilon) chains with 4 Ig-like constant domains, and two light chains
• IgE plays an essential role in type I hypersensitivity (allergic responses such as hay fever, asthma, hives, anaphylatic shock) by binding to Fc receptors on basophils and mast cells
• Crosslinking of IgE bound to Fc receptors induces degranulation of mast cells and basophils that promote allergic manifestations
• IgE is also functionally important for immunity against parasites.