CD183 Mouse anti-Human, Alexa Fluor 488, Clone: 1C6/CXCR3, BD

Description

• Clone 1C6/CXCR3 reacts with the human form of the 40 - 41kDa seven-transmembrane protein and member of the G protein-coupled receptor family
• CXCR3 is expressed primarily on activated T cells that infiltrate inflammatory sites
• It has also been detected on some circulating T cells, B cells, and NK cells
• Reports show that some CXCR3 T cells also express CCR5 and are mostly CD45RO cells
• Three ligands for CXCR3 have been identified
• They are interferon-γ inducible 10kDa protein (IP-10), monokine induced by interferon-γ (MIg), and interferon-inducible T-cell γ chemoattractant (I-TAC)
• These chemokines are produced by a variety of cells upon stimulation by IFN γ and interact with CXCR3 to mediate T-cell chemotaxis
• This reagent has been reported to be suitable for immunohistochemical staining of acetone-fixed, frozen sections and/or formalin-fixed, paraffin-embedded tissue sections with citrate pretreatment
• Clone CXCR3 also cross reacts with a subset of peripheral blood lymphocytes of baboon, and both rhesus and cynomolgus macaque monkeys
• The distribution of lymphocytes is similar to that observed with peripheral blood lymphocytes from normal human donors
• CXCR3 has been clustered as CD183 in the VIIth HLDA workshop
• This product is routinely tested by flow cytometric analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature
• Host Species: Mouse Clone: 1C6/CXCR3 Isotype: IgG1, κ Cross Reactivity: Human Flow Cytometry