Pericentrin Mouse anti-Mouse, Unlabeled, Clone: 30, BD

Description

• Centrosomes and other microtubule-organizing centers are a diverse group of organelles that nucleate and organize microtubules for many celllular processes, such as mitotic spindle formation, organelle tranpsort, and protein localization
• Pericentrin is a protein in the pericentriolar material, a filamentous matrix surrounding centrioles, which can organize microtubule spindle formation
• The structure of pericentrin includes multiple α-helical domains that form coiled-coil domains separated by non-helical, non-coiled regions
• It is found in a 3MDa-complex that includes γ-tubulin, a form of tubulin that nucleates microtubule formation at the centrosome
• Pericentrin exhibits the highest expression in embryonic mouse kidney, thymus, and liver
• Injection of pericentrin antibodies in Xenopus oocytes disrupts mitotic and meiotic divisions and blocks microtubule aster formation
• In addition, dynein transports both pericentrin and γ-tubulin to centrosomes along microtubules in Xenopus oocyte extracts
• Thus, the complex of pericentrin and γ-tubulin may be recruited to the centrosome by dynein, where the complex becomes anchored to the centrosome for microtubule nucleating activity
• Host Species: Mouse Clone: 30 Isotype: IgG1 Species Reactivity [for Features Main]: Human Immunogen: Mouse pericentrin aa
• 1692-1814 Immunofluorescence, Western Blotting