3851559

Rab5 Mouse, Unlabeled, Clone: 1, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Antigen

Rab5

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgG2a

Purification Method

Affinity Purified

Clone

1

Applications

Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Canine, Human

Immunogen

Human Rab5 aa. 1-215

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

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Description

  • Rab5 is a low molecular weight GTP-binding protein that plays a role in endocytic vesicle traffic
  • Like other Rab proteins, Rab5 has C-terminal cysteine residues that are post translationally modified by geranylgeranylation which is critical for its membrane targeting
  • Rab5 is associated with early endosome and plasma membranes and evidence suggests that Rab5 regulates early endosome fusion
  • The GTP/GDP cycle controls shuttling of Rab proteins between the cytosol and membranes
  • In vitro, Rab5 proteins are removed from membranes by a GDP dissociation inhibitor protein (rabGDI) which leads to the formation of a cytosolic Rab5-rabGDI complex
  • Rab5 may insert into membranes by a multistep process in a which a transient GDP-Rab5 intermediate is formed and converted into GTP-Rab5 that subsequently enters the acceptor membrane and releases rabGDI into the cytosol
  • Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

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Show Difference

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3851559

Mouse Monoclonal Antibody...


Antigen:
Rab5

Concentration:
250μg/mL

Classification:
Monoclonal

Host Species:
Mouse

Research Discipline:
Cell Biology

Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype:
IgG2a

Purification Method:
Affinity Purified

Clone:
1

Applications:
Western Blot

Conjugate:
Unconjugated

Regulatory Status:
RUO

Target Species:
Canine, Human

Immunogen:
Human Rab5 aa. 1-215

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at -20°C.

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Concentration:
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Monoclonal

Host Species:
Mouse

Research Discipline:
Cell Biology

Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype:
IgG1

Purification Method:
Affinity Purified

Clone:
35

Applications:
Immunofluorescence, Western Blot

Conjugate:
Unconjugated

Regulatory Status:
RUO

Target Species:
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Immunogen:
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Conjugate:
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Concentration:
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Classification:
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Host Species:
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Research Discipline:
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Isotype:
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Purification Method:
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Clone:
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Applications:
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Conjugate:
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Regulatory Status:
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Target Species:
Human, Mouse, Rat

Immunogen:
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Primary or Secondary:
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