3855690
c-Raf Mouse, Unlabeled, Clone: 53, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
c-Raf
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG1
Purification Method
Affinity Purified
Clone
53
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Canine, Chicken, Human, Mouse, Rat
Immunogen
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
Description
- Raf (c-Raf-1) is a cytoplasmic serine/threonine protein kinase and is a member of a family of proteins which are highly conserved from Drosophila to mammals
- Raf has a critical role in the response to many growth factors including: EGF, PDGF, insulin, IL-2, IL-3, CSF-1, and GM-CSF
- Raf can directly interact with Ras-GTP and subsequently become activated
- Thus Raf plays a prominent role in the Ras signaling pathway by transferring a signal from Ras which has been activated by growth factor receptor-stimulated tyrosine kinase activity
- This leads to the stimulation and activation of a number of other cytoplasmic serine/threonine kinases
- Raf regulates the MAP kinase pathway by phosphorylating and activating MEK, which then phosphorylates and activates MAP kinase (ERK)
- ERK then phosphorylates and activates Rsk
- Raf activity can also be regulated independently of Ras
- Cyclic AMP (cAMP) activation of protein kinase A (PKA) can inhibit growth factor stimulation of Raf.
Compare Similar Items
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Antigen: c-Raf
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 53
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Chicken, Human, Mouse, Rat
Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
c-Raf
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
53
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Chicken, Human, Mouse, Rat
Immunogen:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: β-Catenin
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 14
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Chicken, Human, Mouse, Rat
Immunogen: Mouse β-Catenin aa. 571-781
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
β-Catenin
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
14
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Chicken, Human, Mouse, Rat
Immunogen:
Mouse β-Catenin aa. 571-781
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: PKA [RI]
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG2b
Purification Method: Affinity Purified
Clone: 18
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Chicken, Frog, Human, Mouse, Rat
Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
PKA [RI]
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG2b
Purification Method:
Affinity Purified
Clone:
18
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Chicken, Frog, Human, Mouse, Rat
Immunogen:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: PKCι
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG2b
Purification Method: Affinity Purified
Clone: 23
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Chicken, Human, Mouse, Rat
Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
PKCι
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG2b
Purification Method:
Affinity Purified
Clone:
23
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Chicken, Human, Mouse, Rat
Immunogen:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.