3855690

c-Raf Mouse, Unlabeled, Clone: 53, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

c-Raf

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgG1

Purification Method

Affinity Purified

Clone

53

Applications

Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Canine, Chicken, Human, Mouse, Rat

Immunogen

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

Description

  • Raf (c-Raf-1) is a cytoplasmic serine/threonine protein kinase and is a member of a family of proteins which are highly conserved from Drosophila to mammals
  • Raf has a critical role in the response to many growth factors including: EGF, PDGF, insulin, IL-2, IL-3, CSF-1, and GM-CSF
  • Raf can directly interact with Ras-GTP and subsequently become activated
  • Thus Raf plays a prominent role in the Ras signaling pathway by transferring a signal from Ras which has been activated by growth factor receptor-stimulated tyrosine kinase activity
  • This leads to the stimulation and activation of a number of other cytoplasmic serine/threonine kinases
  • Raf regulates the MAP kinase pathway by phosphorylating and activating MEK, which then phosphorylates and activates MAP kinase (ERK)
  • ERK then phosphorylates and activates Rsk
  • Raf activity can also be regulated independently of Ras
  • Cyclic AMP (cAMP) activation of protein kinase A (PKA) can inhibit growth factor stimulation of Raf.

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Mouse Monoclonal Antibody...


Antigen:
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Concentration:
250μg/mL

Classification:
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Host Species:
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Research Discipline:
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Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype:
IgG1

Purification Method:
Affinity Purified

Clone:
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Applications:
Western Blot

Conjugate:
Unconjugated

Regulatory Status:
RUO

Target Species:
Canine, Chicken, Human, Mouse, Rat

Immunogen:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at -20°C.

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Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype:
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Purification Method:
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Conjugate:
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Store undiluted at -20°C.

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Concentration:
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Host Species:
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Research Discipline:
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Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype:
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Purification Method:
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Regulatory Status:
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Content And Storage:
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