3855821
Cadherin-5 Mouse anti-Human, Unlabeled, Clone: 75, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Cadherin-5
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG1
Purification Method
Affinity Purified
Clone
75
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Human
Immunogen
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
Description
- Cadherins are a family of transmembrane glycoproteins involved in the Ca 2 + - dependent cell-cell adhesion that occurs in many tissues
- These proteins are similar in their domain structure (45-74% amino acid conservation), Ca 2 + and protease-sensitivity, and molecular weight
- Cadherin-5 (VE-Cadherin or CD144) is one of a number of cadherins (cadherin-4 through -11) whose cDNAs were isolated from rat brain and retina
- These cadherins have a cytoplasmic domain that is highly conserved relative to previously identified cadherins, indicating that this domain is essential for cell adhesion activity
- This function is mediated by cadherin interaction with cytoskeletal proteins
- However, Cadherin-5's cytoplasmic domain has the lowest degree of homology with the other cadherins
- Cadherin-5 is expressed in brain and various other tissues, including umbilical cord vein endothelial cells
- A new type of adhering junction has been identified in certain vascular endothelial cells
- These junctions are known as “complexus adherens” and are morphologically and compositionally distinct from desmosomes and zonula adherens junctions
- The complexus adherens of endothelial cells lack desmosomal cadherins as well as E-Cadherin
- However, these cells are rich in Cadherin-5 which colocalizes with desmoplakin and γ-Catenin (plakoglobin)
- Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Compare Similar Items
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Antigen: Cadherin-5
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 75
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Cadherin-5
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
75
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Immunogen:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: γ-Catenin
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG2a
Purification Method: Affinity Purified
Clone: 15
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Chicken, Human, Mouse, Rat
Immunogen: Human γ-Catenin aa. 553-738
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
γ-Catenin
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG2a
Purification Method:
Affinity Purified
Clone:
15
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Chicken, Human, Mouse, Rat
Immunogen:
Human γ-Catenin aa. 553-738
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: Rb2
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG2a
Purification Method: Affinity Purified
Clone: 10
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Chicken, Drosophila, Human, Mouse, Rat
Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Rb2
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG2a
Purification Method:
Affinity Purified
Clone:
10
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Chicken, Drosophila, Human, Mouse, Rat
Immunogen:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: CD45
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Immunology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 69
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human, Mouse, Rat
Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
CD45
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Immunology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
69
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human, Mouse, Rat
Immunogen:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.