3856065

β-Arrestin Mouse, Unlabeled, Clone: 10, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

β-Arrestin

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgG1

Purification Method

Affinity Purified

Clone

10

Applications

Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Human, Mouse, Rat

Immunogen

Rat β-Arrestin1 aa. 262-409

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

Description

  • β-Arrestins were discovered due to their ability to modulate interactions between the phosphorylated β2-Adrenergic receptors and G proteins
  • This modulation results in diminished β2-Adrenergic receptor function, also known as desensitization
  • Because arrestins are found at the synaptic terminals, they may provide a termination mechanism that allows the neurons to regain their original polarization and respond to a new neurotransmitter stimulus
  • The C-terminal region of arrestins is involved in selecting the phosphorylated and activated adrenergic receptors
  • The β-Arrestin1 gene encodes a protein of 418 amino acids with an approximate molecular weight of 55kDa
  • β-Arrestin1 protein is highly homologous to the 45kDa β-Arrestin2
  • Both proteins are widely expressed, but are especially abundant in the central nervous system
  • Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

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Antigen:
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250μg/mL

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Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

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Store undiluted at -20°C.

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