3968610
CD11b Rat anti-Mouse, APC, Clone: M1/70, BD
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD11b
Concentration
0.2mg/mL
Classification
Monoclonal
Host Species
Rat
Target Species
Human, Mouse
Isotype
IgG2b κ
Purification Method
Affinity Purified
Description
Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Clone
M1/70
Applications
Flow Cytometry
Conjugate
APC
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or α;M)
- CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family
- CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, α;Mβ;2), also known as complement receptor 3 (CR3)
- Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi
- Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes
- Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface
- The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis
- Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.
Compare Similar Items
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Antigen: CD11b
Concentration: 0.2mg/mL
Classification: Monoclonal
Host Species: Rat
Target Species: Human, Mouse
Isotype: IgG2b κ
Purification Method: Affinity Purified
Description: Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Clone: M1/70
Applications: Flow Cytometry
Conjugate: APC
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD11b
Concentration:
0.2mg/mL
Classification:
Monoclonal
Host Species:
Rat
Target Species:
Human, Mouse
Isotype:
IgG2b κ
Purification Method:
Affinity Purified
Description:
Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Clone:
M1/70
Applications:
Flow Cytometry
Conjugate:
APC
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD11b
Concentration: 0.2mg/mL
Classification: Monoclonal
Host Species: Rat
Target Species: Human, Mouse
Isotype: IgG2b κ
Purification Method: Affinity Purified
Description: Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Clone: M1/70
Applications: Flow Cytometry
Conjugate: PE-Cyanine7
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD11b
Concentration:
0.2mg/mL
Classification:
Monoclonal
Host Species:
Rat
Target Species:
Human, Mouse
Isotype:
IgG2b κ
Purification Method:
Affinity Purified
Description:
Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Clone:
M1/70
Applications:
Flow Cytometry
Conjugate:
PE-Cyanine7
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD11b
Concentration: __
Classification: Monoclonal
Host Species: Mouse
Target Species: Human
Isotype: IgG1 κ
Purification Method: Affinity Purified
Description: Mac-1α, integrin αM subunit, CR3 α chain
Clone: ICRF44
Applications: Flow Cytometry
Conjugate: Violet Fluor 450 (V450)
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD11b
Concentration:
__
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Human
Isotype:
IgG1 κ
Purification Method:
Affinity Purified
Description:
Mac-1α, integrin αM subunit, CR3 α chain
Clone:
ICRF44
Applications:
Flow Cytometry
Conjugate:
Violet Fluor 450 (V450)
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD11c
Concentration: 0.2mg/mL
Classification: Monoclonal
Host Species: Hamster
Target Species: Mouse
Isotype: __
Purification Method: Affinity Purified
Description: Cd11c; Itgax; Integrin alpha-X; Integrin αX; Cr4; Complement receptor 4
Clone: HL3
Applications: Flow Cytometry
Conjugate: APC
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD11c
Concentration:
0.2mg/mL
Classification:
Monoclonal
Host Species:
Hamster
Target Species:
Mouse
Isotype:
__
Purification Method:
Affinity Purified
Description:
Cd11c; Itgax; Integrin alpha-X; Integrin αX; Cr4; Complement receptor 4
Clone:
HL3
Applications:
Flow Cytometry
Conjugate:
APC
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.