FoxP3 Mouse anti-Human, V450, Clone: 259D/C7, BD

Description

• The 259D/C7 antibody reacts with the human FoxP3 transcription factor, a member of the forkhead or winged helix family of transcription factors
• The expression of FoxP3, also known as Scurfin, IPEX and JM2, has been found to be associated with CD4+ regulatory T cells and represents a specific marker for these cells
• Flow-cytometric analysis has shown that FoxP3 is expressed by the majority of CD4+CD25+high T cells in peripheral blood while less than half of CD4+CD25int cell population are FoxP3 positive
• Approximately 5-10% of peripheral CD4+ cells are CD4+CD25+ T regulatory cells
• T regulatory cells are thought to play a critical role in the control of T cell mediated autoimmunity by suppressing the proliferation and cytokine production of other T cells
• To support this hypothesis, it has been found that FOXP3 is mutated in scurfy (sf) mice
• The 259D/C7 antibody reacts with all currently identified isoforms of human FoxP3 and is cross-reactive with Cynomolgus, Rhesus and Baboon
• The antibody is conjugated to BD Horizon™ V450, which has been developed for use in multicolor flow cytometry experiments and is available exclusively from BD Biosciences
• It is excited by the Violet laser Ex max of 406nm and has an Em Max at 450nm
• Conjugates with BD Horizon™ V450 can be used in place of Pacific Blue™ conjugates
• Host Species: Mouse Clone: 259D/C7 Isotype: IgG1 Species Reactivity: Human Immunogen: FoxP3 recombinant protein Intracellular Staining