3970797
Hic5 Mouse, Unlabeled, Clone: 34, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Hic5
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG1
Purification Method
Affinity Purified
Clone
34
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Canine, Human, Mouse, Rat
Immunogen
Mouse Hic-5 aa. 73-186
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- Focal adhesions are cell structures terminal to the actin-stress fiber bundles
- They attach cultured cells to their substratum or extracellular matrix
- These adhesions occur through the integrin receptor molecules which link cytoskeletal proteins and extracellular matrix
- The intracellular adhesion is composed of a number of proteins such as paxillin, VASP, vinculin, and the focal-adhesion kinases FAK and PYK2/CAKβ
- Hic-5, also described as hydrogen peroxide inducible-mRNA, is a focal adhesion protein that binds to FAK and PYK2
- It is ubiquitously expressed with the highest levels found in lung, spleen, and heart
- Induction of Hic-5 is accomplished by hydrogen peroxide or TGFβ1 and is repressed in K-ras transformed cells
- Like paxillin, Hic-5 is tyrosine phosphorylated in Src-transformed cells and is highly similar to paxillin in its primary structure
- Both proteins contain LIM domains and LD motifs
- In addition, Hic-5 localizes to focal adhesions and co-immunoprecipitates with PYK2/CAKβ in vivo
- Thus, Hic-5 may be a substrate for CAKβ and play a role in signal transduction during proliferation, cell motility, and adhesion
- Host Species: Mouse Clone: 34 Isotype: IgG1 Species Reactivity: Rat Immunogen: Mouse Hic-5 aa
- 73-186 Formula Weight [Chemical]: 50kDa Immunofluorescence, Western Blotting
Compare Similar Items
Show Difference
Antigen: Hic5
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 34
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Human, Mouse, Rat
Immunogen: Mouse Hic-5 aa. 73-186
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Hic5
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
34
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Human, Mouse, Rat
Immunogen:
Mouse Hic-5 aa. 73-186
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: Hsp60
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 24/HSP60
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human, Mouse, Rat
Immunogen: Human Hsp60 aa. 1-200
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Hsp60
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
24/HSP60
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human, Mouse, Rat
Immunogen:
Human Hsp60 aa. 1-200
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: IL-10
Concentration: 0.5mg/mL
Classification: Monoclonal
Host Species: Rat
Research Discipline: Immunology
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG2a
Purification Method: Affinity Purified
Clone: JES3-19F1
Applications: ELISA
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human, Virus
Immunogen: Recombinant Human IL-10
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
IL-10
Concentration:
0.5mg/mL
Classification:
Monoclonal
Host Species:
Rat
Research Discipline:
Immunology
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG2a
Purification Method:
Affinity Purified
Clone:
JES3-19F1
Applications:
ELISA
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human, Virus
Immunogen:
Recombinant Human IL-10
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: IL-17A
Concentration: 0.2mg/mL
Classification: Monoclonal
Host Species: Rat
Research Discipline: Immunology
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG1 κ
Purification Method: Affinity Purified
Clone: TC11-18H10
Applications: Flow Cytometry
Conjugate: Alexa Fluor 488
Regulatory Status: RUO
Target Species: Mouse
Immunogen: __
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
IL-17A
Concentration:
0.2mg/mL
Classification:
Monoclonal
Host Species:
Rat
Research Discipline:
Immunology
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG1 κ
Purification Method:
Affinity Purified
Clone:
TC11-18H10
Applications:
Flow Cytometry
Conjugate:
Alexa Fluor 488
Regulatory Status:
RUO
Target Species:
Mouse
Immunogen:
__
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.