3971855
ROCK-I Mouse, Unlabeled, Clone: 46, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
ROCK-I
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG1
Purification Method
Affinity Purified
Description
ROKβ
Clone
46
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Human, Mouse, Rat
Immunogen
Mouse ROCK-I aa. 906-1012
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
Related Products
Description
- ROCK-I is a Rho-associated serine/threonine kinase isozyme that mediates RhoA-induced assembly of focal adhesions and actin stress fibers
- It contains an N-terminal kinase domain, a central 600 amino acid long coiled-coil region, a C-terminal pleckstrin homology region (PH) and a Cys-rich zinc finger motif
- The ROCK-I kinase domain is approximately 90% identical to that of ROCK-II
- ROCK-I binds GTP-bound Rho through a Rho-binding domain (RBD)
- As a result, the kinase activity of ROCK-I is moderately stimulated
- The ROCK isozymes regulate cell contractility through phosphorylation of the myosin light chain
- This effect results from either the inhibition of the myosin phosphatase or by direct phosphorylation of the myosin light chain, thus bypassing the myosin light chain kinase
- In addition, ROCK-I activates the ubiquitously expressed Na-H exchanger (NHE1) via a number of mechanisms including RhoA
- NHE1 may mediate ROCK-I-induced changes in the actin cytoskeleton
- Therefore, ROCK-I plays an important role in the regulation of focal adhesion and stress fiber formation
- Host Species: Mouse Clone: 46 Isotype: IgG1 Species Reactivity: Mouse Immunogen: Mouse ROCK-I aa
- 906-1012 Formula Weight [Chemical]: 160kDa Immunofluorescence, Western Blotting
Compare Similar Items
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Antigen: ROCK-I
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Description: ROKβ
Clone: 46
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human, Mouse, Rat
Immunogen: Mouse ROCK-I aa. 906-1012
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
ROCK-I
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Description:
ROKβ
Clone:
46
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human, Mouse, Rat
Immunogen:
Mouse ROCK-I aa. 906-1012
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: TCR β chain
Concentration: 0.5mg/mL
Classification: Monoclonal
Host Species: Hamster
Research Discipline: Immunology
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG2
Purification Method: Affinity Purified
Description: __
Clone: H57-597
Applications: Flow Cytometry
Conjugate: Biotin
Regulatory Status: RUO
Target Species: Mouse
Immunogen: TCR affinity-purified from mouse T-cell hybridoma DO-11.10
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
TCR β chain
Concentration:
0.5mg/mL
Classification:
Monoclonal
Host Species:
Hamster
Research Discipline:
Immunology
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG2
Purification Method:
Affinity Purified
Description:
__
Clone:
H57-597
Applications:
Flow Cytometry
Conjugate:
Biotin
Regulatory Status:
RUO
Target Species:
Mouse
Immunogen:
TCR affinity-purified from mouse T-cell hybridoma DO-11.10
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: TCR β chain
Concentration: 0.5mg/mL
Classification: Monoclonal
Host Species: Hamster
Research Discipline: Immunology
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG2
Purification Method: Affinity Purified
Description: __
Clone: H57-597
Applications: Flow Cytometry
Conjugate: FITC
Regulatory Status: RUO
Target Species: Mouse
Immunogen: TCR affinity-purified from mouse T-cell hybridoma DO-11.10
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
TCR β chain
Concentration:
0.5mg/mL
Classification:
Monoclonal
Host Species:
Hamster
Research Discipline:
Immunology
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG2
Purification Method:
Affinity Purified
Description:
__
Clone:
H57-597
Applications:
Flow Cytometry
Conjugate:
FITC
Regulatory Status:
RUO
Target Species:
Mouse
Immunogen:
TCR affinity-purified from mouse T-cell hybridoma DO-11.10
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: TER-119/Erythroid Cells
Concentration: 0.5mg/mL
Classification: Monoclonal
Host Species: Rat
Research Discipline: Immunology
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG2b κ
Purification Method: Affinity Purified
Description: Lymphocyte antigen 76; Ly76; Ly-76; TER-119; Ter119
Clone: TER-119
Applications: Flow Cytometry
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Mouse
Immunogen: Mouse Fetal Liver
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
TER-119/Erythroid Cells
Concentration:
0.5mg/mL
Classification:
Monoclonal
Host Species:
Rat
Research Discipline:
Immunology
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG2b κ
Purification Method:
Affinity Purified
Description:
Lymphocyte antigen 76; Ly76; Ly-76; TER-119; Ter119
Clone:
TER-119
Applications:
Flow Cytometry
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Mouse
Immunogen:
Mouse Fetal Liver
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C