3970838
Hsp60 Mouse, Unlabeled, Clone: 24/HSP60, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Hsp60
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG1
Purification Method
Affinity Purified
Clone
24/HSP60
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Human, Mouse, Rat
Immunogen
Human Hsp60 aa. 1-200
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- Heat shock proteins (Hsp) are a set of highly conserved proteins that include constitutively expressed (Hsp60, Hsp70, and Hsp90) and stress-induced (Hsp27 and Hsp72) proteins
- Hsp60 is localized to the mitochondria, where it promotes mitochondrial protein folding and facilitates proteolytic degradation of misfolded or denatured proteins
- It binds Hsp10, which regulates the substrate binding and ATPase activity of Hsp60
- In HeLa and Jurkat mitochondria, Hsp60 associates with caspase-3 to form a complex that dissociates and releases from the mitochondria during apoptosis
- In addition, Hsp60 accelerates the maturation of procaspase-3 through its ATP-dependent “foldase” activity
- In addition to its role in protein folding, Hsp60 has also been implicated in immune function
- In macrophages, its binding to the toll-like receptor-4 complex induces production of TNFα and nitric oxide and stimulation of a proinflammatory response
- Thus, the protein folding function of Hsp60 is involved in mitochondrial protein folding in both normal and apoptotic cells, while release of Hsp60 during necrosis is thought to stimulate a proinflammatory response
- Host Species: Mouse Clone: 24 Isotype: IgG1 Species Reactivity: Human Immunogen: Human Hsp60 aa
- 1-200 Formula Weight [Chemical]: 60kDa Immunofluorescence, Western Blotting
Compare Similar Items
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Antigen: Hsp60
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 24/HSP60
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human, Mouse, Rat
Immunogen: Human Hsp60 aa. 1-200
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Hsp60
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
24/HSP60
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human, Mouse, Rat
Immunogen:
Human Hsp60 aa. 1-200
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: IL-10
Concentration: 0.5mg/mL
Classification: Monoclonal
Host Species: Rat
Research Discipline: Immunology
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG2a
Purification Method: Affinity Purified
Clone: JES3-19F1
Applications: ELISA
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human, Virus
Immunogen: Recombinant Human IL-10
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
IL-10
Concentration:
0.5mg/mL
Classification:
Monoclonal
Host Species:
Rat
Research Discipline:
Immunology
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG2a
Purification Method:
Affinity Purified
Clone:
JES3-19F1
Applications:
ELISA
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human, Virus
Immunogen:
Recombinant Human IL-10
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: IL-17A
Concentration: 0.2mg/mL
Classification: Monoclonal
Host Species: Rat
Research Discipline: Immunology
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG1 κ
Purification Method: Affinity Purified
Clone: TC11-18H10
Applications: Flow Cytometry
Conjugate: Alexa Fluor 488
Regulatory Status: RUO
Target Species: Mouse
Immunogen: __
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
IL-17A
Concentration:
0.2mg/mL
Classification:
Monoclonal
Host Species:
Rat
Research Discipline:
Immunology
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG1 κ
Purification Method:
Affinity Purified
Clone:
TC11-18H10
Applications:
Flow Cytometry
Conjugate:
Alexa Fluor 488
Regulatory Status:
RUO
Target Species:
Mouse
Immunogen:
__
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: IL-17A
Concentration: __
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Immunology
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype: IgG1 κ
Purification Method: Affinity Purified
Clone: SCPL1362
Applications: Flow Cytometry
Conjugate: Alexa Fluor 647
Regulatory Status: RUO
Target Species: Human
Immunogen: __
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
IL-17A
Concentration:
__
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Immunology
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype:
IgG1 κ
Purification Method:
Affinity Purified
Clone:
SCPL1362
Applications:
Flow Cytometry
Conjugate:
Alexa Fluor 647
Regulatory Status:
RUO
Target Species:
Human
Immunogen:
__
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.