CD304 (Neuropilin-1) Monoclonal Antibody (TNKUSOHA), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Description

• The TNKUSOHA MAb recognizes human CD304, which is also known as BDCA-4 and Neuropilin-1
• Like CD303, the CD304 antigen is expressed on human plasmacytoid dendritic cells in normal blood and bone marrow
• CD304 can also be detected on T follicular helper cells in inflamed tonsils, as well as on some B-cell acute lymphoblastic leukemias
• In addition, CD304 is expressed on numerous non-hematopoietic cell types, including neurons, endothelial, and tumor cells
• Plasmacytoid dendritic cells play a key role in the innate immune response against viral pathogens and tumors
• Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain
• Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors
• Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system
• This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis
• Neuropilin 1 may be involved in aggressive advanced prostate carcinoma and in the progression of breast cancer.